This federal Project Grant award of $811,112 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research by the University of California, San Francisco (UCSF) to investigate the brain networks and neural signaling mechanisms that underlie sudden "insight" learning of cue-reward associations. The key objectives are to use advanced techniques like two-photon calcium imaging, high-density...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 - Drug Use and Addiction Research Programs, provides $201,250 to New York University (NYU) to characterize the synaptic organization and function of cholinergic interneurons in the nucleus accumbens (NAc) core region of the mouse brain. The 2-year project (6/1/2025 - 5/31/2027) will use a combination of anatomy, slice electrophysiology, and optogenetics to examine how diverse excitatory and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,080,885 to the University of Southern California (USC) from September 2024 to September 2027. The funding supports the development of novel neural network models that can capture the nonlinear dynamics of large-scale brain networks and their relationship to behavior. The models will have flexible inference capabilities, enabling real-time,...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is focused on validating a novel computational neurobiological model of costly drug-taking behavior centered on the striosomes of the dorsomedial striatum. The $1,766,868 award to the University of Texas at El Paso will use electrophysiology, optogenetics, and advanced modeling techniques to investigate the role of the prelimbic-striosomal and...
This $252,714.59 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) is funding research to examine the role of the basolateral amygdala in encoding inhibitory reward associations. The goal is to reveal the neuronal mechanisms by which inhibitory reward associations are established, which can provide insights into flexible, adaptive decision-making and impairments seen in substance use disorders. The research, conducted at the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $836,348 to the Icahn School of Medicine at Mount Sinai to conduct research examining the interplay between cannabis craving and addictive decision-making. The key objectives are to: 1) identify a computational algorithm to model the bidirectional relationship between craving and choice, 2) investigate the temporal dynamics of the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the CFDA program "Drug Use and Addiction Research Programs" (93.279), will support research to uncover the neurophysiological signatures within the addiction circuitry related to acute opioid use. The $159,711 award, effective January 1, 2025 through December 31, 2029, will leverage a unique ability to directly record local field potentials from awake humans with implanted brain electrodes. This will...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...