Project Grant R01DA060859

Award Date 4/1/25
Completion Date 1/31/30
Dollars Obligated $704K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Durham, NC 27710, USA
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The key objectives are to: 1) assess the impact of smoking withdrawal on brain activity in response to noxious heat stimuli, and 2) examine how withdrawal-induced hyperalgesia influences the ability to abstain from smoking. The project will enroll 96 adults who smoke daily, with and without chronic pain, and conduct fMRI scans and a 1-week smoking abstinence test to address these research questions. Findings from this work are expected to provide a foundation for developing targeted interventions to aid smoking cessation, particularly among individuals with comorbid chronic pain.

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