Project Grant R01DA063421
- The National Institute on Drug Abuse awarded New York University $411,187 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic research on trial-to-trial variability in neural circuits and its impact on neural computation and behavioral accuracy. The project integrates theoretical models, statistical methods, and experimental datasets to characterize noise in neural circuits using rodent navigation and nonhuman primate decision-making tasks. The...
- The National Institute on Drug Abuse awarded President and Fellows of Harvard College $120,937 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on the control of behavioral and neural variability during perceptual decision-making under uncertainty. The research combines computational modeling with human behavioral experimentation and neuroimaging to investigate whether individuals can increase the accuracy of perceptual decisions by...
- The National Institute on Drug Abuse awarded the Regents of the University of Michigan $325,904 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop real-time machine learning methods for constructing and perturbing stimulus-shaped neural manifolds. The project deliverables span three aims: developing real-time dimensionality reduction algorithms to construct neural manifolds shaped by external stimulus information; designing probabilistic models for...
- The National Institute on Drug Abuse awarded The University of Chicago $390,600 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop coarse-graining theory, models, and methods that translate approaches to describing emergent collective behavior in neural systems into usable code for the broad neuroscience community. The project will produce data analysis code made available to neuroscience researchers for use on their own datasets. Three theorists...
- The National Institute on Drug Abuse awarded Northwestern University $722,218 on March 1, 2026, for research on the effects of developmental environment on dopamine circuit structure and function under the Drug Use and Addiction Research Programs (CFDA 93.279). The project runs through December 31, 2030, with place of performance in Chicago, Illinois. The research investigates how early life stress produces long-lasting impacts on dopamine circuit function and development into adulthood, using...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,080,885 to the University of Southern California (USC) from September 2024 to September 2027. The funding supports the development of novel neural network models that can capture the nonlinear dynamics of large-scale brain networks and their relationship to behavior. The models will have flexible inference capabilities, enabling real-time,...
- The National Institute on Drug Abuse awarded the Lieber Institute Inc. $1.855 million on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop three-dimensional cellular resolution spatio-molecular maps of the human nucleus accumbens across its anterior-posterior axis. The nucleus accumbens is a key node in the brain's reward circuitry, and perturbations in reward signaling are implicated in substance use disorders. The project extends prior spatial...
- The National Institute on Drug Abuse awarded Duke University $446,651 under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 1, 2026, for Project Grant R01DA066620. The award funds development, validation, and delivery of a platform for relating natural behavior to neural activity in animal models. The platform will build on foundation models of the brain using machine learning and large-scale neural networks trained across diverse datasets collected from different...
- The National Institute on Drug Abuse awarded the University of North Carolina at Chapel Hill $427,625 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support mapping neural circuit and network contributions to addiction development. The project introduces a novel MRI-compatible cocaine self-administration system integrating calcium imaging with fMRI (termed SORDINO-fMRI) to enable simultaneous recording of neuronal activity in the medial prefrontal cortex and...
- The National Institute on Drug Abuse awarded Yale University $336,250 on April 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop a behavioral foundation model that transforms qualitative epidemiological survey responses into quantitative representations of substance use behaviors. The project harmonizes data from the National Epidemiologic Survey on Alcohol and Related Conditions III (NESARC-III), National Survey on Drug Use and Health (NSDUH), and UK Biobank...
The National Institute on Drug Abuse awarded The Trustees of Princeton University $473,543 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop theoretical frameworks and computational methods for identifying mechanisms of cognitive computations from neural recordings and behavioral data. The award funds three research aims: formulating mathematical theory relating the dimensionality of neural population dynamics to single-cell selectivity patterns and testing this theory using brain-wide neural recordings; developing a convex computational framework for efficiently fitting recurrent neural network models to data with flexible rank control; and developing methods for designing effective neural stimulation patterns. The work addresses a gap in current neuroscience by providing circuit-level mechanistic understanding of how heterogeneous single-neuron responses generate low-dimensional population dynamics during cognitive tasks, with direct application to predicting outcomes of targeted perturbation experiments in behaving animals. Performance occurs at Princeton, New Jersey, with a period extending from September 1, 2026, through June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $473.5k | 9/1/26 |