Project Grant R01DA067964
- The National Institute on Drug Abuse awarded New York University $411,187 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic research on trial-to-trial variability in neural circuits and its impact on neural computation and behavioral accuracy. The project integrates theoretical models, statistical methods, and experimental datasets to characterize noise in neural circuits using rodent navigation and nonhuman primate decision-making tasks. The...
- The National Institute on Drug Abuse awarded The Trustees of Princeton University $473,543 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop theoretical frameworks and computational methods for identifying mechanisms of cognitive computations from neural recordings and behavioral data. The award funds three research aims: formulating mathematical theory relating the dimensionality of neural population dynamics to single-cell selectivity patterns...
- The National Institute of Mental Health awarded President and Fellows of Harvard College $674,028 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the determinants and function of tonic dopamine signaling in the striatum. The research develops and applies real-time measurement methods to distinguish tonic dopamine (slowly changing baseline levels) from phasic dopamine (rapid transient signals) in mice across multiple behavioral contexts. The project...
- The National Institute of Neurological Disorders and Stroke awarded President and Fellows of Harvard College $579,740 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Harvard Medical School will conduct research to identify cell types and circuits that signal errors and their role in updating expectations for learning and cognitive flexibility. The work spans five years through March 31, 2031, performed in Boston,...
- The National Institute on Drug Abuse awarded $493,444 to The Regents of the University of California, operating Lawrence Berkeley National Laboratory, on March 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The research examines feedback controllability of neural population dynamics, specifically how feedback control principles shape neural activity patterns underlying brain functions from perception to cognition and action. The project develops normative theories...
- The National Institute on Drug Abuse awarded Boston Children's Hospital $800,131 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the functions and mechanisms of a molecularly defined prefrontal cortex neuron subtype in drug addiction. The research focuses on identifying and characterizing POU3F1-expressing layer 5 neurons in the prefrontal cortex and their role in regulating cocaine-seeking behavior. The work employs single-cell RNA sequencing...
- The National Institute on Drug Abuse awarded Yale University $336,250 on April 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop a behavioral foundation model that transforms qualitative epidemiological survey responses into quantitative representations of substance use behaviors. The project harmonizes data from the National Epidemiologic Survey on Alcohol and Related Conditions III (NESARC-III), National Survey on Drug Use and Health (NSDUH), and UK Biobank...
- The National Institute on Drug Abuse awarded a cooperative agreement to Massachusetts General Hospital totaling $1.352 million on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). Massachusetts General Hospital will develop an inexpensive, wearable functional near-infrared spectroscopy (fNIRS) device and integrated software to detect and assess cerebral biomarkers of drug intoxication in real-world settings. The device, designated iFlexNIRS, will feature eight...
- The National Institute of Mental Health awarded $452,386 to President and Fellows of Harvard College on September 1, 2026, to study the plasticity of synaptic cotransmission in the mouse lateral habenula under the Mental Health Research Grants program (CFDA 93.242). The research investigates how changes in the valence of learned associations induce synaptic plasticity in the lateral habenula—a brain structure implicated in mood disorders—and subsequently alter downstream dopamine signaling....
- The National Institute on Drug Abuse awarded the Regents of the University of Michigan $325,904 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop real-time machine learning methods for constructing and perturbing stimulus-shaped neural manifolds. The project deliverables span three aims: developing real-time dimensionality reduction algorithms to construct neural manifolds shaped by external stimulus information; designing probabilistic models for...
The National Institute on Drug Abuse awarded President and Fellows of Harvard College $120,937 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on the control of behavioral and neural variability during perceptual decision-making under uncertainty. The research combines computational modeling with human behavioral experimentation and neuroimaging to investigate whether individuals can increase the accuracy of perceptual decisions by controlling the precision of sensory evidence accumulation through motivated, effortful control. The project derives normative principles for controlling computational noise in perceptual decision-making by trading off expected improvements in decision accuracy against the intrinsic effort cost of control. Researchers will test predictions about how motivation, reward, prior beliefs, and expectancies affect noise control through behavioral experiments, magnetoencephalography recordings to characterize the neural patterns and time course of decision-related brain activity, and comparison of neural geometry to predictions from artificial recurrent neural networks trained on identical tasks. A longitudinal online study will link individual differences in noise-control ability to cognitive traits and subclinical psychiatric symptoms. The work is performed at Harvard Medical School in Boston, Massachusetts, under the auspices of Harvard College's Office of Research Administration. The period of performance runs from September 1, 2026, through July 31, 2030. This is a Project Grant, the standard NIH research funding mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $120.9k | 9/1/26 |