Project Grant R21DA066213
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $230,421 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded June 1, 2026, with completion scheduled for May 31, 2027. This research project investigates the effect of genetic background on functional brain networks activated in response to cocaine using whole-brain imaging techniques. The research leverages tissue clearing...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $1.74M Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded September 30, 2025, with completion targeted for May 31, 2030. The grant funds research investigating cell type and circuit-specific epigenetic mechanisms underlying cocaine addiction. Using a novel methodology combining inducible barcoded rabies virus with...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA), under its Drug Use and Addiction Research Programs (CFDA 93.279), awarded $877,500 to the University of California, San Diego for a two-year project (July 15, 2025 through June 30, 2027) investigating neurobiological mechanisms underlying cocaine use disorder (CUD) susceptibility. The project employs a novel polygenic prediction methodology called RATTACA to identify pre-existing cellular differences in gabaergic and...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Lieber Institute for Brain Development a Project Grant of $1.855 million under the Drug Use and Addiction Research Programs (CFDA 93.279), effective March 1, 2026 through February 28, 2029. The grant funds development of three-dimensional cellular-resolution spatio-molecular maps of the human nucleus accumbens (NAC), a critical brain region implicated in reward signaling and substance use disorders. The primary...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Boston Children's Hospital a $800,131 Project Grant effective May 1, 2026, through February 28, 2031, under the Drug Use and Addiction Research Programs (CFDA 93.279). This award supports basic neuroscience research investigating the functions and mechanisms of a molecularly defined prefrontal cortex (PFC) neuron subtype in drug addiction. The research focuses on characterizing POU3F1-expressing layer 5 neurons...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded UC San Diego a $197,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through August 31, 2027. The award supports development and validation of an in vivo Massively Parallel Reporter Assay (MPRA) methodology to characterize the functional role of cis-regulatory elements and genetic variants associated with substance use disorders. Specifically, the...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $1.4M Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, through May 31, 2030. The award funds translational research to identify nociceptin/orphanin FQ peptide (NOP) receptors as pharmacological targets for treating cocaine use disorder (CUD). The research leverages nonhuman primate models combined with...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of North Carolina at Chapel Hill $1,407,350 under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and test a novel therapeutic approach targeting HIV's persistent central nervous system (CNS) reservoir. The grant, awarded August 15, 2025 with completion by May 31, 2030, funds research into transcriptional inactivation of the HIV reservoir using TAT-targeting lipid...
- Federal Grant Award Summary The University of South Carolina received a $192,149 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded February 1, 2026, with completion targeted for January 31, 2028. This award funds research investigating the noradrenergic mechanisms underlying stress-induced opioid reinstatement, with a focus on understanding how stress-related neural activity drives opioid-seeking behaviors....
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded SUNY Downstate Health Sciences University a $6.94 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a longitudinal investigation of neighborhood conditions, neural circuits, and substance use behaviors across the early life course. The award, effective September 30, 2025, through June 30, 2029, addresses the multifactorial etiology of substance use disorders...
The National Institute on Drug Abuse (NIDA) awarded the University of North Carolina at Chapel Hill a $427,625 Project Grant on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and operate an integrated neuroimaging and behavioral analysis system for studying cocaine addiction mechanisms. The primary deliverable is the SORDINO-fMRI system, a novel magnetic resonance imaging-compatible self-administration apparatus that combines real-time calcium imaging of neuronal activity in the medial prefrontal cortex with whole-brain functional MRI (fMRI) recording during cocaine self-administration experiments in animal models. This integrated platform enables simultaneous capture of microscale neuronal dynamics and macroscale brain network activity, addressing a critical gap in addiction research methodology. Over the two-year project period (July 1, 2026 through June 30, 2028), the research team will deliver three key research products: (1) longitudinal neuronal and network data characterizing how salience, default mode, and lateral control networks dynamically couple with drug-seeking behavior across addiction development phases; (2) network-level analysis identifying organizational changes associated with the emergence of compulsive drug use; and (3) functional characterization of anterior insula inhibition effects on medial prefrontal cortex function and compulsive behavior suppression. These outputs are designed to establish mechanistic linkages between acute neural responses and persistent network-level adaptations underlying addiction, with potential application to development of targeted therapeutic interventions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 6/23/26 |