Project Grant R01DA061810
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,876 to conduct preclinical trials targeting the neuropeptide S (NPS) receptor to mitigate opioid taking and seeking behaviors in animal models. The goals of the project are to demonstrate proof-of-concept that NPS receptor-targeted molecules can reduce oxycodone self-administration and motivation in rats, which could inform the...
- This federal Project Grant award of $623,650 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant is funding research at Oregon Health & Science University to investigate how adolescent social isolation and disruption of thyroid hormone signaling in the basolateral amygdala may contribute to substance use disorder vulnerability. The project aims to elucidate the...
- This federal Project Grant award for $330,027.00 from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research to develop a computational-experimental framework for characterizing the complex dynamics of naturalistic social interaction across neural, behavioral, and social scales. The project will utilize simultaneously recorded behavioral and electrophysiology data from ferrets during natural social interactions to construct multiscale...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
- This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, supports research under the Drug Use and Addiction Research Programs (CFDA 93.279) on the interplay between norepinephrine and dopamine circuits in the brain and their role in sex differences in reward and aversion. The $781,032 award, spanning August 2025 to April 2030, will map the anatomical and neurochemical distribution of norepinephrine projections from the locus...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the Drug Use and Addiction Research Programs (CFDA 93.279), provides $237,600 to The Pennsylvania State University to study the neural mechanisms underlying opioid consumption. The project aims to characterize sex differences in resting-state functional connectivity (RSFC) in mice before and after voluntary morphine consumption to determine if RSFC can predict vulnerability to initial opioid use. The long-term...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $759,339 to The Trustees of the University of Pennsylvania to support research on the role of central amylin receptors in opioid-mediated behaviors. The research aims to comprehensively define the functional roles of cell type-specific ventral tegmental area (VTA) and nucleus accumbens (NAc) amylin receptors in opioid taking and seeking...
- This $403,542 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to profile projection-specific proteome associated with the incubation of oxycodone craving. The project will focus on the orbitofrontal cortex (OFC) to dorsal striatum (DS) projections, analyzing proteome changes in OFC neuronal somas (Aim 1) and OFC-DS projection-specific synaptoneurosomes in the DS (Aim 2) during the incubation of oxycodone...
- This federal Project Grant award of $650,250 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to investigate the neural mechanisms underlying motivational and cognitive deficits associated with opioid withdrawal. The project aims to uncover the role of dopamine and acetylcholine signaling, as well as the activity of striatal projection neurons, in mediating withdrawal-induced reductions in motivation and...
This federal Project Grant award of $718,146, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the role of oxytocin and social bonding in facilitating the extinction of amphetamine reward in the prairie vole animal model. The research aims to investigate how social connection and social interaction can prevent and reduce drug use and dependence, as well as facilitate drug reward extinction. Using the socially monogamous prairie vole, the project will explore the neurobiological mechanisms underlying the interactions between social bonding and addictive behaviors, with a focus on the neurotransmitter oxytocin. This research will leverage the unique characteristics of the prairie vole to provide insights into the complex relationships between social environments and substance use disorders. The award period extends from August 15, 2025 to April 30, 2030, supporting this comprehensive research program at Florida State University.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $718.1k | 8/1/25 |