This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $562,014 to the University of California, San Diego (UCSD) for a project titled "Opioid Actions on the Habenulo-Peduncular Circuit". The project aims to investigate the role of the medial habenula and interpeduncular nucleus in mediating the aversive qualities of opioid dependence and withdrawal, using a combination of molecular, physiological, and behavioral approaches in mice. Specifically, the research will focus on identifying the cell types in these brain regions that express the mu-opioid receptor, how receptor signaling influences this circuit, and whether chronic opioid exposure induces physiological changes that contribute to withdrawal. The project will run from September 15, 2024 to July 31, 2029, with the goal of informing the development of new therapeutic approaches to prevent or treat opioid use disorder.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $562.0k | 9/5/24 |