Project Grant R01DA060914

Award Date 5/1/25
Completion Date 2/28/30
Dollars Obligated $752K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This $247,875 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the CFDA 93.279 Drug Use and Addiction Research Programs supports a study to examine the potential effectiveness of transcranial direct current stimulation (tDCS) paired with reappraisal training for treating cannabis use disorder (CUD). The project will recruit 60 participants and assign them to receive either real or sham tDCS alongside reappraisal training, measuring changes in cannabis use...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to determine how specific neurological markers can predict responses to repetitive transcranial magnetic stimulation (rTMS) treatments for substance use disorders (SUDs). The $816,604 award will be used to identify neuromarkers of reward reactivity and cognitive control that moderate the effectiveness of rTMS interventions targeting the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $180,606 to the Icahn School of Medicine at Mount Sinai (ISMMS) to investigate the interplay between drug-induced long-term synaptic proteomic adaptations and underlying transcriptional responses within the brain's reward regions. The research aims to elucidate the cell-type and circuit-specific synaptic proteome changes in the nucleus...
This $180,646 Project Grant award, issued by the National Institute on Drug Abuse (NIDA) under the Federal Grant Program CFDA 93.279 - Drug Use and Addiction Research Programs, will support research to investigate the molecular mechanisms underlying astrocytic CREB's regulation of cocaine drug-seeking behavior. The research, to be conducted at the Icahn School of Medicine at Mount Sinai, aims to elucidate the astrocyte transcriptome and its epigenetic regulation in the context of drug addiction....
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,624,920.00 to support a randomized clinical trial conducted by the Lovelace Biomedical Research Institute. The study aims to demonstrate the reliability and generalizability of improved outcomes in offenders with substance use disorders by matching specific cognitive deficits with targeted skills training interventions. The research will...
This federal Project Grant award, valued at $1,478,199.00 and funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the differential roles of prefrontal cortical interneurons in drug-seeking behavior after withdrawal from cocaine. The primary objectives are to: 1) monitor the activity of distinct interneuron subtypes in the infralimbic cortex during cocaine self-administration, 2) directly...
This $1,076,018 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support a randomized clinical trial of DCH-003, a digital therapeutic developed by Dynamicare Health Inc. to deliver contingency management (CM) for the treatment of stimulant use disorder. The study aims to evaluate the efficacy of DCH-003, which automates CM through remote, self-administered saliva tests and integrates evidence-based therapy...
This federal Project Grant award for $671,981.00 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund research to investigate the role of cortical excitatory projections in cocaine addiction, with a focus on the supplementary motor cortex (M2) and its connections to the dorsolateral striatum. The 5-year project aims to 1) examine the excitability of pyramidal neurons in the M2 region, 2) assess...
This $498,429 Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants supports research by the Children's Research Institute to identify the multi-modal factors that determine individual response to transcranial direct current stimulation (tDCS). The project aims to leverage a large existing database of concurrent tDCS-fMRI data, cognitive/behavioral measures, and anatomical models to determine the key predictors of an...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on investigating a specialized serotonergic-septohippocampal circuit that may influence the vulnerability for relapse in substance use disorders. The $254,250 award, spanning from July 2024 to June 2026, will support the delineation of the intrinsic properties and transmission interactions of a novel neuronal cell type (LSI-R2P) that is modulated...

This Project Grant award from the National Institute on Drug Abuse (NIDA, NIH CFDA 93.279 - Drug Use and Addiction Research Programs) provides $752,166 to the Icahn School of Medicine at Mount Sinai to conduct research on using transcranial direct current stimulation (tDCS) combined with cognitive training to reduce craving and improve inhibitory control in individuals with cocaine use disorder.

The project aims to evaluate the synergistic effects of administering tDCS over the dorsolateral prefrontal cortex while participants undergo cognitive reappraisal training to drug cues. The goal is to enhance prefrontal cortical function and reduce craving, thereby decreasing drug use and relapse in this population. The study will be conducted over a 5-year period through May 2030 and includes a double-blind, randomized trial with four treatment groups to assess the clinical efficacy of this novel intervention approach. Exploratory analyses will also investigate neuroimaging biomarkers predictive of treatment outcomes.

Generated 5/13/25, 4:55 AM