This federal Project Grant award of $800,617.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports the development and validation of neuromarkers - measurable, brain-based indicators of pathophysiology, risk, and resilience related to substance use disorders (SUDs). The project, titled "NEUROMARKERS FOR CRAVING AND DRUG USE", aims to build upon previous research that created a cross-validated neuromarker...
This Project Grant award of $159,615 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to predict craving and relapse in opioid use disorder using neurobehavioral markers of goals and habits. The key objectives are to: Track daily changes in motivational control during inpatient heroin addiction treatment with and without fentanyl use, to understand how goal-directed control evolves with abstinence. Use the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $180,646 to the Icahn School of Medicine at Mount Sinai to investigate the molecular mechanisms by which astrocytic CREB regulation influences cocaine addiction-related behavior. The research aims to elucidate the underlying transcriptional and epigenetic regulation of astrocytes in the context of drug abuse and addiction. Key activities...
This Project Grant award of $142,656 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to understand the neural mechanisms underlying craving and its impact on decision-making in food addiction. The award will fund a study that induces craving through multisensory food cues and examines how craving differentially affects subjective value computations for craved and non-craved foods in individuals with and without...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is focused on validating a novel computational neurobiological model of costly drug-taking behavior centered on the striosomes of the dorsomedial striatum. The $1,766,868 award to the University of Texas at El Paso will use electrophysiology, optogenetics, and advanced modeling techniques to investigate the role of the prelimbic-striosomal and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is funding a $1,585,991 study to evaluate the efficacy of combining transcranial direct current stimulation (tDCS) with cognitive reappraisal training to reduce craving and reactivity to drug cues in individuals with cocaine use disorder. The study, being conducted at the Icahn School of Medicine at Mount Sinai, will perform a double-blind...
This federal Project Grant award of $811,112 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research by the University of California, San Francisco (UCSF) to investigate the brain networks and neural signaling mechanisms that underlie sudden "insight" learning of cue-reward associations. The key objectives are to use advanced techniques like two-photon calcium imaging, high-density...
This federal Project Grant award, with ID R01DA065418, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $390,687 grant will support research at New York University (NYU) to characterize how the orbitofrontal cortex, dorsal striatum, and basolateral amygdala interact to support belief updating and context-dependent decision making, which is relevant for understanding substance use disorders. The research will involve...
The National Institute on Drug Abuse (NIDA) awarded a $818,513 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to the Regents of the University of Minnesota to investigate the role of dopamine signaling in the basolateral amygdala in regulating individual differences in reward-based learning strategies and addiction-like behaviors. The 5-year grant, which commenced on Sep 15, 2024, will focus on examining how individual differences in Pavlovian reward learning approaches...
This $2,118,992 Project Grant, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a longitudinal study investigating the neural and psychiatric consequences of cannabis use in depressed adolescents. The research aims to prospectively examine the effects of cannabis, the most widely used illicit drug among teenagers, on reward and pain neurocircuits in adolescents with depression. The study will evaluate 250...