This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $417,861.00 to investigate the neural mechanisms underlying individual differences in reward-based learning strategies and their relationship to addiction-like behaviors. The 5-year research project, conducted by the Regents of the University of Minnesota, will focus on the role of dopamine signaling in the basolateral amygdala in mediating the...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research into the neural circuitry underlying goal-directed and habit learning behaviors. The $162,672 award, with a performance period from August 1, 2024 to March 31, 2028, will be used by the University of California, Los Angeles (UCLA) to conduct an in-depth investigation of the role of dopaminergic projections to the...
This Project Grant award, with a total funding amount of $206,955.00, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The objective of this research project is to understand how negative affective states, such as those associated with substance use disorder and depression, impact large-scale brain network activity. Specifically, the project will use rodent functional MRI, fiber photometry, and taste reactivity...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $157,568 to Drexel University to elucidate corticolimbic circuit and neuroimmune mechanisms underlying HIV-induced dysregulation of reward-seeking behavior. The research aims to use optogenetic and chemogenetic techniques to stimulate the infralimbic cortex-nucleus accumbens shell circuit and modulate microglial function to rescue HIV-induced...
This Project Grant award, valued at $1,447,919.00 and provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research aimed at understanding the mechanisms underlying cocaine addiction and testing interventions to address it. The key research objectives are to: 1) Evaluate whether treatment with a glucagon-like peptide-1 (GLP-1) receptor agonist can block the aversive behavioral and physiological responses to a...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $800,617 in funding to The Regents of the University of California, Berkeley (UC Berkeley) to develop and validate neuromarkers - measurable, brain-based indicators of pathophysiology, risk, and resilience in substance use disorders (SUDs). The primary objective is to build upon prior research (R01DA043690) that used machine learning and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to develop and experimentally validate a computational neurobiological model of drug-taking behavior involving cost tradeoffs. The $1,766,868 award to the University of Texas at El Paso will fund a 5-year study to investigate the role of the striosomal circuit in mediating the impact of craving on drug-cost tradeoffs and predicting...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $519,501 to support research into the role of hypothalamic GABA and glutamate signaling in motivation for opioid reward. The project aims to investigate the behavioral function and spatiotemporal signaling dynamics of lateral hypothalamus (LHA) neuron subpopulations and their downstream effects on dopaminergic signaling during the development...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to study the neurogenetic mechanisms underlying nicotine and cannabis addiction. The $175,888 award, effective September 1, 2024 through August 31, 2028, will enable the development of novel transcriptome-connectome analysis methods to identify genes associated with changes in brain functional connectivity related to addiction. The...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $142,656 to Rutgers, The State University of New Jersey to conduct research on the neural mechanisms underlying food craving and its impact on decision-making in individuals with food addiction.
The research aims to investigate how craving differentially affects subjective value computations and neural representations of craved versus non-craved foods in individuals with food addiction compared to healthy controls. This will be assessed using functional MRI scans while participants complete willingness-to-pay tasks before and after a craving induction. The findings are expected to provide novel insights into the neural mechanisms driving disproportionate overconsumption of highly palatable foods in food addiction. The award period runs from December 12, 2024 to June 30, 2026.