This $2,419,326 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a longitudinal study to investigate neurobehavioral and psychosocial predictors of health risk behaviors (HRBs) in adolescence and young adulthood. The primary awardee, Virginia Polytechnic Institute & State University, will conduct assessments over 15 years to understand brain development and its impact on substance use and...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This Project Grant award of $781,032 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research to understand the interplay between norepinephrine and dopamine circuits in the brain and their role in sex differences related to reward and aversion, including substance use disorders. Specifically, the research aims to map the anatomical and neurochemical distribution of norepinephrine projections from...
The federal Project Grant award R15DA062968 for $571,675.00, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a forward genetic screen to identify novel genes involved in the mechanisms of amphetamine action. The research, conducted by Florida Atlantic University, aims to elucidate how amphetamine, a commonly abused psychostimulant, generates addiction by investigating physiological and behavioral modifications...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is focused on validating a novel computational neurobiological model of costly drug-taking behavior centered on the striosomes of the dorsomedial striatum. The $1,766,868 award to the University of Texas at El Paso will use electrophysiology, optogenetics, and advanced modeling techniques to investigate the role of the prelimbic-striosomal and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $346,911 cross-species research study to identify early life environmental and genetic risk factors for substance use disorders (SUDs). The key objectives are to: 1) determine how early life environment influences neurocognitive development and its relationship to adult impulsivity behaviors; 2) identify genomic networks associated...
This Project Grant award, totaling $400,294, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The funding supports research to investigate the neurobiological mechanisms by which adverse childhood experiences (ACEs) and chronic stress alter the rewarding effects of the synthetic opioid fentanyl. Specifically, the project aims to determine the therapeutic potential of the serotonin 2A receptor (5-HT2AR) in modulating...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $720,763 to Virginia Commonwealth University (VCU) to investigate the risk and protective factors associated with substance use trajectories in adolescents. The 4-year study will leverage data from the Adolescent Brain Cognitive Development (ABCD) study, which includes a large, nationwide sample of over 11,000 youth, as well as longitudinal...
This Project Grant award, valued at $629,844.00, was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award will support research at Duke University to elucidate the function of the ventral tegmental area (VTA) circuits and their contribution to the learning and performance of motivated behaviors. The research will use bidirectional optogenetics, in vivo electrophysiology and photometry, and quantitative behavioral...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...