This Project Grant award of $135,906 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research on the impact of perinatal fentanyl exposure on the development of the mesolimbic dopamine pathway and associated behavioral outcomes. The research aims to use differential gene expression, morphological analysis, and fiber photometric recording to investigate how perinatal fentanyl exposure affects the structure and function...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the impact of fentanyl consumption on noradrenergic plasticity in the basolateral amygdala. The $184,706 award to the University of North Carolina at Chapel Hill will fund a 5-year study to investigate how patterns of fentanyl consumption and withdrawal alter brainstem noradrenergic neurons and disrupt norepinephrine signaling in the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a research project entitled "Optimizing Developmental Outcomes in Early Childhood After Neonatal Opioid Withdrawal Syndrome." The $180,059 award, effective August 1, 2024, will fund a 5-year longitudinal study to assess the independent and moderating effects of positive childhood experiences (PCEs) and adverse childhood experiences...
The National Institute on Drug Abuse (NIDA) awarded a $135,765 project grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Washington to investigate the role of corticotropin-releasing factor (CRF) in modulating accumbal dopamine and producing escalation of drug intake. The research aims to 1) test the necessity of CRF receptor 1 in the nucleus accumbens (NAc) for the escalation of drug taking, and 2) examine the modulation of phasic dopamine response...
This Project Grant award of $134,556 was provided by the National Institute on Drug Abuse (NIDA) under the federal Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research to determine the role of a specific subpopulation of astrocytes (CRYM+ astrocytes) within the nucleus accumbens (NAc) region of the brain and their contribution to goal-directed behaviors and opioid use disorder. The research aims to characterize the basic biological properties of NAc astrocytes,...
This federal Project Grant award for $340,000 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research to better understand the role of the locus coeruleus-noradrenergic (LC-NE) system in fentanyl withdrawal-induced negative affect behaviors. The research aims to determine whether a newly identified midbrain glutamatergic input to the LC contributes to the negative affective behaviors associated with opioid withdrawal....
This Project Grant award, valued at $192,500.00 and provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to understand the effects of gestational fentanyl exposure on the offspring of pregnant women. The research aims to measure the impact on offspring morbidity, mortality, developmental milestones, external morphology, blood cholesterol, brain morphology and neurochemistry, and neonatal opioid withdrawal. The...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,073,250 to the University of California, San Diego (UCSD) to investigate age-related differences in opioid reward and addiction. The funded studies will use rat models to determine how the middle-adult developmental stage may influence sensitivity to prescription opioids, heroin, and fentanyl, compared to younger adulthood. The research aims...
This Project Grant award of $250,568.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund a 3-year research project to investigate the neurobiological mechanisms underlying individual and sex differences in emotional cue processing related to addiction and post-traumatic stress disorder. The award recipient, the Regents of the University of Michigan, will use chemogenetic and fiber photometry techniques to gain control...
This Project Grant award of $781,032 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research to understand the interplay between norepinephrine and dopamine circuits in the brain and their role in sex differences related to reward and aversion, including substance use disorders. Specifically, the research aims to map the anatomical and neurochemical distribution of norepinephrine projections from...