This $779,969 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to improve perioperative care for patients with opioid use disorder. The key objectives are to: Prospectively capture patient-reported pain and opioid use data among individuals with opioid use disorder undergoing common surgical procedures, and develop evidence-based prescribing guidelines. Qualitatively assess the perioperative experiences...
This $399,536 Project Grant was awarded by the National Institute on Drug Abuse (NIDA), a part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research to design, synthesize, and test non-opioid drug candidates that can help combat the national opioid crisis, with a focus on reversing the effects of synthetic opioids like fentanyl. The key goals are to: 1) Develop and characterize chemical lead compounds and control...
This federal Project Grant award of $2,542,500.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will develop novel econometric methods and a unified framework for integrating real-world evidence (RWE) into the analysis of inconclusive randomized controlled trials (RCTs) for opioid use disorder (OUD) treatments. The project will evaluate multiple maximum likelihood estimation (MLE) approaches combined with propensity...
This $701,959 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to improve perioperative care for patients with opioid tolerance in the United States. The key objectives are to: Prospectively capture patient-reported opioid use and pain outcomes among opioid-tolerant individuals undergoing common surgical procedures, and develop a clinical care pathway to optimize outcomes across a network of hospitals...
This $715,238 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support a large-scale genome-wide association study (GWAS) of opioid-related traits in a diverse population of 500,000 individuals. The University of California, San Diego (UCSD) is the primary awardee and will work to uncover the genetic basis of the pre-addiction stages of opioid use, such as initial use, subjective response, and...
This $233,250 Project Grant was awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University in St. Louis. The grant will fund a 2-year data analysis study to examine the relationship between early cannabis use and subsequent opioid use disorder, including the potential roles of adverse childhood experiences, genetic liability, and comorbid stimulant use. The project aims to provide insights into whether...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop advanced statistical methods for improving the effectiveness and efficiency of clinical trials for treating opioid use disorder. The primary objectives are to: Develop efficient parametric and semiparametric estimators for average treatment effects, conditional average treatment effects, and optimal individualized treatment rules...
This federal Project Grant award of $1,213,117 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The objective is to develop novel chemical probes targeting the sodium binding site of the mu opioid receptor (MOR) to achieve functional selectivity and therapeutic benefits. The primary products/services include: Synthesis and pharmacological characterization of bitopic ligands that engage both the orthosteric and...
This Project Grant award of $1,362,860 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a study on the co-use of cannabis and prescription opioids among emerging adults in medical settings. The study aims to identify individual risk factors and malleable protective factors that contribute to the development of opioid and cannabis co-use and related problems in the context of pain management. The research will...
This $159,711 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports a study titled "Electrophysiological Dynamics of Acute Opioid Use in Human Reward, Affect, and Pain Pathways." The project aims to investigate how acute opioid administration impacts neural connectivity within brain regions associated with opioid use disorder (OUD), including the amygdala, hippocampus, prefrontal cortex, and pain...
This $680,595 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support a 5-year research project to systematically analyze over 3.1 million internal industry documents obtained through opioid litigation. The project aims to assess how prescription opioid manufacturers marketed their products as safe and non-addictive to patients, healthcare providers, and regulators, contributing to high opioid prescribing and consumption rates. By leveraging novel artificial intelligence-guided search methods to examine this unprecedented trove of industry documents, the research seeks to identify the specific marketing strategies and messaging used to promote opioids, with the goal of informing future regulatory actions on addictive pharmaceuticals. The project is being conducted by the Regents of the University of California, San Francisco, a prominent academic medical center and research institution.