Project Grant R01CA317052
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $716,319 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded June 11, 2026, with an ultimate completion date of May 31, 2031. The award supports research optimization of CD45-targeted Astatine-211 radioimmunotherapy for malignant and non-malignant blood disorders. The research advances alpha-emitter-based radioimmunotherapy by developing improved monoclonal...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $714,192 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) awarded June 1, 2026, with completion targeted for May 31, 2031. The project delivers a novel lung cancer subtype-specific risk stratification approach designed to address critical limitations in current low-dose computed tomography (CT) lung cancer screening protocols. The deliverables...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center $169,776 under the Cancer Research Manpower program (CFDA 93.398) for a two-year project (August 1, 2025–July 31, 2027) titled "Unraveling Myeloid-Mediated Mechanisms of Immunotherapy Resistance in Prostate Cancer Bone Metastases at Single-Cell Resolution." This project grant funds biomedical research training and investigator-initiated research focused on identifying and...
- Federal Grant Award Summary Fred Hutchinson Cancer Center received a $712,569 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), awarded May 4, 2026 and extending through April 30, 2031. The grant supports research investigating the impact of KEAP1 and NRF2 (Nuclear Factor Erythroid 2-Related Factor 2) pathway mutations on chemotherapy response in small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC). The...
- Summary of Federal Grant Award This National Cancer Institute (NCI) Project Grant, awarded under the Cancer Biology Research program (CFDA 93.396), provides $723,547 to Fred Hutchinson Cancer Center in Seattle, Washington to investigate the role of 5' untranslated regions (5' UTRs) in prostate cancer clonal heterogeneity and growth dynamics. The award, obligated on June 9, 2026, with a completion date of May 31, 2031, funds fundamental research aimed at identifying how distinct 5' UTR regions...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Institute For Cancer Research a $766,439 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) effective April 1, 2026, through March 31, 2031. This research initiative addresses the clinical challenge of bladder cancer patients avoiding radical cystectomy by investigating intratumor heterogeneity as a predictor of clinical outcomes. The project delivers two primary research...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $760,396 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded June 15, 2026, with performance completion targeted for May 31, 2031. This grant funds a research initiative investigating metabolomic mechanisms contributing to prostate cancer (PCA) risk across multiple populations. The primary deliverable is the generation and analysis of...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $439,639 Project Grant to Fred Hutchinson Cancer Center (operating as Seattle Cancer Care Alliance) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective June 1, 2026 through May 31, 2031. The award funds the development of methods and tools for microsimulation model calibration—a critical process for ensuring that computational cancer screening models are accurately calibrated to...
- Federal Project Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research a $745,471 Project Grant effective July 1, 2026, through June 30, 2031, under the Cancer Treatment Research program (CFDA 93.395). This research initiative, titled "Hematopoietic Stem Cell Encoded Anti-Tumor Immunity: Mechanisms and Function," focuses on elucidating the mechanisms of action underlying Bacillus Calmette-Guerin (BCG) immunotherapy for non-muscle...
- Federal Grant Award Summary The National Cancer Institute awarded Fred Hutchinson Cancer Center a $737,945 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) on May 4, 2026, for work through April 30, 2029. The project will develop flexible, quantitative measurement tools to assess provider and intervention characteristic determinants of evidence-based interventions (EBIs) in cancer care settings. Using Item Response Theory (IRT), the research team will create...
Award Details: Fred Hutchinson Cancer Center received $752,751 from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on July 2, 2026, with completion targeted for June 30, 2031. The award supports research conducted at the organization's Seattle, Washington facility. Research Products and Services: The funded project delivers comprehensive research services aimed at deciphering tumor heterogeneity, metastatic spread, and treatment resistance in advanced metastatic bladder cancer. Specifically, the award supports three integrated research aims: (1) delineating the role of polyclonal seeding from oligometastatic disease in driving aggressive, treatment-resistant metastatic bladder cancer; (2) elucidating the role of the Fanconi anemia pathway in modulating cisplatin sensitivity; and (3) supporting the Fred Hutch/University of Washington Bladder Cancer Rapid Autopsy Program—a unique resource that collects tumors and matched benign tissues from deceased patients within hours of death and conducts multi-omic profiling including whole genome sequencing, RNA-sequencing (RNA-seq), and post-mortem circulating tumor DNA analysis. The research leverages existing specimens and data from 34 patients (20 with completed multi-omic profiling) to advance understanding of mechanisms driving poor prognosis and identify potential therapeutic targets, particularly through localized interventions such as radiation therapy for early oligometastatic disease.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $752.8k | 7/3/26 |