Project Grant R01CA303804
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $591,419 Project Grant under the Cancer Treatment Research program (CFDA 93.395) for the period May 1, 2026 through April 30, 2031. This award supports the development of low molecular weight theranostics targeting cluster of differentiation 38 (CD38) protein for multiple myeloma patients. The research deliverables include creation of an 18-fluorine labeled positron emission tomography (PET)...
- Federal Grant Award Summary Fred Hutchinson Cancer Center received a $712,569 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded on May 4, 2026, with a completion date of April 30, 2031. The grant supports research investigating the impact of KEAP1/NRF2 pathway activation on therapy response in lung neuroendocrine cancers, specifically small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC). The research...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center a $723,547 Project Grant under the Cancer Biology Research program (CFDA 93.396) on June 9, 2026, with a completion date of May 31, 2031. This five-year research initiative investigates the role of 5' untranslated regions (5' UTRs) in prostate cancer clonality and heterogeneity. The project delivers fundamental research on how distinct 5' UTR regions modulate protein synthesis and...
- Federal Grant Award Summary The National Cancer Institute awarded a $736,168 Project Grant to Sloan-Kettering Institute for Cancer Research (award date: August 1, 2025; completion date: July 31, 2030) under the Cancer Treatment Research program (CFDA 93.395) to develop novel antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugates (AOCs) designed to enhance radiotherapy efficacy through antigen-specific radiosensitization. The research focuses on delivering potent DNA damage...
- Federal Grant Award Summary The National Cancer Institute awarded Johns Hopkins University a $155,479 Project Grant under the Cancer Treatment Research program (CFDA 93.395) beginning June 1, 2026 and concluding May 31, 2028. This award supports the development and preclinical validation of an anti-CCRL2 (C-C motif receptor-like 2) antibody-drug conjugate (ADC) designed to treat high-risk myelodysplastic syndrome (MDS) and MDS-related acute myeloid leukemia (AML) in patients with TP53...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center a Project Grant of $714,192 under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective June 1, 2026, through May 31, 2031. This award funds the development and validation of a novel lung cancer subtype-specific risk stratification approach designed to overcome critical limitations in current low-dose computed tomography (CT) screening protocols. The project will...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center $169,776 under the Cancer Research Manpower program (CFDA 93.398) for a two-year project (August 1, 2025–July 31, 2027) titled "Unraveling Myeloid-Mediated Mechanisms of Immunotherapy Resistance in Prostate Cancer Bone Metastases at Single-Cell Resolution." This project grant funds biomedical research training and investigator-initiated research focused on identifying and...
- Federal Grant Award Summary The National Cancer Institute awarded Fred Hutchinson Cancer Center a $739,640 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025, through August 31, 2030. This award supports the development and validation of methods to advance early detection of pancreatic ductal adenocarcinoma (PDAC) by leveraging electronic medical records (EMR) data. The project addresses the critical public health challenge that...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center a Project Grant totaling $139,184 under the Cancer Research Manpower program (CFDA 93.398) for the period of July 1, 2025, through June 30, 2027. This award funds research investigating the role of RNA components of the translation apparatus in prostate cancer plasticity and therapy response. The project focuses on elucidating how prostate cancer leverages transfer RNA (tRNA) and 5'...
The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center a $716,319 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 11, 2026, with a completion date of May 31, 2031. This award supports research to optimize CD45-targeted Astatine-211 radioimmunotherapy for treating malignant and non-malignant blood disorders. The project builds on institutional expertise with the murine monoclonal antibody BC8, advancing from earlier beta-emitter approaches (Iodine-131) to alpha-emitter technology that delivers higher decay energy over shorter distances for more precise target cell killing. The research deliverables include development and optimization of Astatine-211-BC8-B10 conjugates to augment hematopoietic cell transplantation conditioning regimens, with three early-phase clinical trials currently underway to evaluate anti-tumor efficacy in patients with blood cancers and non-malignant blood disorders. The project addresses key limitations of current approaches, including infusion toxicities, human antimouse antibody responses, and tissue residualization from Astatine-211 atom oxidation. The ultimate objective is to enhance therapeutic outcomes while reducing treatment-related complications for patients with relapsed/refractory acute myeloid leukemia and other hematologic malignancies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $716.3k | 6/12/26 |