Project Grant K99CA304360

Award Date 8/1/25
Completion Date 7/31/27
Dollars Obligated $170K
Federal Grant Program
93.398
Assistance Type
Project Grant
Place of Performance
Washington, USA
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  • Utilizing mouse models and patient bone biopsies to determine if a specific granulocyte subset (CD62LhiCXCR2hi-Gran) mediates immunotherapy resistance through IL-1R signaling, and whether inhibiting this mechanism can enhance the efficacy of immune checkpoint inhibitors.
  • Investigating whether prostate cancer-associated macrophages (SPP1hi-TAMs) can modulate the bone-associated myeloid landscape and whether inhibiting their interactions can improve immunotherapy outcomes.
  • Evaluating whether signaling through factors like CCL5 is necessary for the progression of immunosuppressive myelopoiesis in prostate cancer bone metastases.

This 2-year award runs from August 1, 2025 to July 31, 2027 and aims to identify novel cellular and molecular therapeutic targets to improve immunotherapy for metastatic castration-resistant prostate cancer patients with bone metastases.

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