Project Grant R01CA299906
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,129 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on July 15, 2025, with a completion date of June 30, 2027. This award supports research to develop and evaluate improved cancer treatment methods through laboratory and clinical investigation. Specifically, the research leverages a DDX3 inhibitor called RK-33 to alter the metabolic tumor environment in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a $249,000 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for a three-year project period from January 1, 2026 through December 31, 2028. The grant supports the development of large-scale artificial intelligence (AI) and deep learning (DL) tools to improve clinical outcomes in nuclear medicine imaging, specifically addressing reproducibility and generalizability...
- Federal Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research a $452,540 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on July 11, 2025, with a completion date of June 30, 2027. This award supports the development of a novel T-cell imaging paradigm utilizing positron emission tomography (PET) agents targeting CD8 and CD4 markers to provide real-time monitoring of endogenous T-cell trafficking, tumor...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $144,193 to The Johns Hopkins University, effective September 4, 2025, through August 31, 2030, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394). This award provides salary support for Dr. Preethi Korangath to serve as a Laboratory Research Specialist in Dr. Robert Ivkov's laboratory, where she will facilitate the completion of ongoing R01 research projects. Dr. Korangath's protected...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a Project Grant totaling $162,080 under the Cancer Research Manpower program (CFDA 93.398) on December 27, 2025, with a completion date of June 30, 2028. Dr. Komatsu's laboratory is conducting research to visualize and characterize B cell infiltration and aggregation within the tumor microenvironment, with particular focus on the role of high endothelial venules (HEVs) as critical gateways for...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $510,431 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2025 through June 30, 2030. This award supports fundamental research investigating the mechanisms of metastatic recurrence and therapeutic resistance in melanoma, with particular emphasis on understanding how aging influences tumor dormancy and the microenvironment. The research examines Wnt signaling...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $433,256 under the Cancer Treatment Research program (CFDA 93.395) for the period of September 1, 2025 through August 31, 2027. This award supports exploratory research into the role of antisense ribonucleic acids (asRNAs) in melanoma development and transformation. The project will deliver scientific research and analysis focused on...
- Federal Grant Award Summary The National Cancer Institute awarded a $736,168 Project Grant to Sloan-Kettering Institute for Cancer Research (award date: August 1, 2025; completion date: July 31, 2030) under the Cancer Treatment Research program (CFDA 93.395) to develop novel antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugates (AOCs) designed to enhance radiotherapy efficacy through antigen-specific radiosensitization. The research focuses on delivering potent DNA damage...
- Federal Grant Award Summary The National Cancer Institute awarded a $646,881 Project Grant to the Regents of the University of Michigan (Office of Research and Sponsored Projects) under the Cancer Treatment Research program (CFDA 93.395) for the period April 1, 2026, through March 31, 2031. This research project focuses on developing and evaluating small molecule inhibitors targeting ASH1L (Absent, Small or Homeotic 1-Like), a histone methyltransferase protein implicated in acute leukemia...
The National Cancer Institute awarded Johns Hopkins University a $591,419 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective May 1, 2026 through April 30, 2031. This award supports the development of low molecular weight (LMW) theranostics—a paired diagnostic and therapeutic agent—targeting CD38 (Cluster of Differentiation 38) protein for multiple myeloma treatment and detection. The project deliverables include creation of an 18F-labeled positron emission tomography (PET) imaging agent for improved prognostication of multiple myeloma and a potent Actinium-225 (225Ac)-based targeted alpha-emitter therapy (TAT) to deliver selective cytotoxicity directly to malignant plasma cells. The research addresses a critical unmet clinical need in multiple myeloma management by developing peptide-based theranostic tools that overcome therapy-resistant disease progression and provide non-invasive whole-body disease assessment capabilities. By leveraging LMW platforms that demonstrate more tractable pharmacokinetics than biological alternatives, this five-year project aims to advance precision oncology approaches in a disease where all patients eventually relapse despite current standard treatments including proteasome inhibitors, immunomodulatory drugs, hematopoietic stem cell transplantation, and monoclonal antibodies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $591.4k | 4/9/26 |