Project Grant R01CA298456
Award Date
1/1/25
Completion Date
12/31/29
Dollars Obligated
$681K
Federal Agency
National Cancer Institute
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60611, USA
Similar Awards
This $107,860 Project Grant, awarded by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to understand the functional role of fibroid subtype mutations in developing new targeted therapies for uterine fibroids. The research aims to 1) determine the functional roles of HMGA2 over-expression and MED12 mutation in uterine fibroids, 2) predict and test drug compounds to target...
This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) in the amount of $1,624,100 is funding research to understand the role of the REST and MED12 tumor suppressors in the pathogenesis of uterine leiomyomas (fibroids). The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) is the prime awardee, and they have a sub-award with the University of California, San...
This Project Grant award of $2,344,039 from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to identify factors contributing to the racial disparity in the incidence of uterine fibroids between Black and white women. The lead awardee, the Fred Hutchinson Cancer Center, will partner with researchers at Brigham & Women's Hospital and Boston University to: Determine if established fibroid...
This $2,121,229 federal Project Grant award, titled "Evaluating the Impact of Altered Gene Expression on Uterine Fibroid Risk in African Ancestry Populations," was issued by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award aims to leverage the expertise and infrastructure of Vanderbilt University Medical Center (VUMC) and partners in Nigeria to better understand the genetic and...
This $153,000 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to Texas Tech University Health Sciences Center (TTUHSC) aims to develop an anti-cancer approach through a novel pathway of translational regulation. The central focus is on controlling expression of the STAT3 transcription factor, which is upregulated in many tumor types and contributes to cancer progression. The key objectives are to: 1) Identify novel STAT3 translational partners...
This $675,852 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to investigate the pathophysiology of adenomyosis, a common uterine disorder, at the single-cell level. The primary goal is to use advanced single-cell analytics and drug discovery approaches to identify novel or repurposed drugs that can reverse the adenomyosis phenotype and alleviate associated symptoms. The work involves creating a detailed...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) in the amount of $612,288 provides funding to the University of Wisconsin-Madison to conduct research on the role of elevated collagen I and fibronectin in the ovarian cancer pre-metastatic niche for high-grade serous ovarian cancer (HGSOC). The 5-year project, beginning on December 11, 2024 and ending on November 30, 2029, aims to advance the fundamental understanding of the biological...
This $643,049 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a physiomimetic tissue engineering model to investigate the initiation and progression of endometriosis lesions. The research program aims to uncover how the ovarian microenvironment and vascular signals influence the adhesion and invasion of endometriotic epithelial and...
This National Cancer Institute (NCI) Project Grant award under the Cancer Biology Research program (CFDA 93.396) provides $456,103 in funding to The Feinstein Institutes for Medical Research to develop integrated risk models for endometrial cancer. The project aims to enhance early detection of endometrial cancer by determining the burden of rare genetic risk factors and creating predictive models that integrate genetic and non-genetic factors such as BMI, diabetes, and PCOS. The research will...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) provides $499,744 in funding to the Regents of the University of Minnesota to conduct research on the role of STAT5 signaling in tumor-associated macrophages and its impact on breast cancer growth and metastasis. The research aims to better understand how modulating STAT5 activity in macrophages affects the tumor microenvironment and anti-tumor immune responses, with the goal of developing...