This Project Grant award of $2,121,229 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to evaluate the impact of altered gene expression on uterine fibroid risk in African ancestry populations. The key products and services to be delivered include: Testing for the association of known and novel fibroid genome-wide association study (GWAS) loci among Nigerian women...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $229,393 to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on the relationship between early life adversities and the risk of uterine fibroids among Black/African American women. The key products and services to be delivered include: 1) describing the prevalence and...
This Project Grant award of $461,320 from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 (Child Health and Human Development Extramural Research) supports a study on risk factors and consequences of endometriosis among Black women. The award recipient, the Fred Hutchinson Cancer Center, will leverage data from the Black Women's Health Study to evaluate whether established endometriosis risk factors are associated with endometriosis risk in Black women...
This $107,860 Project Grant, awarded by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to understand the functional role of fibroid subtype mutations in developing new targeted therapies for uterine fibroids. The research aims to 1) determine the functional roles of HMGA2 over-expression and MED12 mutation in uterine fibroids, 2) predict and test drug compounds to target...
The National Institute of Child Health and Human Development (NICHD) awarded a $1,487,860 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Colorado-Denver to conduct the "Massachusetts Outcomes Study of Assisted Reproductive Technology Equity" from September 2024 through May 2029. The key objectives of this research project are to: 1) quantify racial/ethnic disparities in maternal and infant health outcomes among women...
This Project Grant award, totaling $1,624,100.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to understand the role of the tumor suppressors REST and MED12 in regulating estrogen-progesterone pathways in uterine fibroids, which are the most common clinical indication for hysterectomy. The research will utilize genetically modified mouse models to...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will provide $178,068 to support Dr. Susanna Mitro's research on the interrelationships between hypertension, antihypertensive treatment, and uterine fibroid diagnosis over a 4-year period from March 2025 to February 2029. The research will utilize data from an integrated healthcare system to: 1) quantify prospective associations between blood pressure trajectories and...
This Project Grant award of $681,337.00 from the National Cancer Institute (NCI) under the Cancer Treatment Research (CFDA 93.395) program supports research to investigate the role of the STAT3 signaling pathway in the growth of uterine leiomyomas (fibroids). The primary awardee, Northwestern University, will determine the functional role of the STAT3 pathway in leiomyoma growth in vivo using a patient-derived xenograft mouse model and single-nucleus multiomics analysis. Two sub-awards to the...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $176,255 to the University of Nevada, Reno to conduct research on the social contextual factors contributing to racial inequities in maternal and infant health outcomes. The study aims to uncover how adolescent social developmental contexts shape biological and social stress pathways that impact maternal health and birth...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $390,000 to Thomas Jefferson University (Sidney Kimmel Medical College) to evaluate the use of contrast-enhanced ultrasound (CEUS) and subharmonic-aided pressure estimation (SHAPE) techniques for assessing uterine fibroids before and after uterine artery embolization (UAE) procedures. The goals...
This Project Grant award of $2,344,039 from the National Institute of Child Health and Human Development (NICHD, CFDA 93.865 Child Health and Human Development Extramural Research) aims to identify factors contributing to the racial disparity in uterine fibroid incidence between Black and White women.
The key products and services to be delivered include:
Analyzing data from the Black Women's Health Study and Nurses' Health Study II cohorts to determine if established fibroid risk factors (e.g. parity, age at menarche, lifestyle) contribute to racial disparities
Examining if environmental, neighborhood-level, and structural racism factors contribute to racial disparities in fibroid risk
Estimating the combined contribution of multiple factors to the fibroid incidence disparity using mediation analysis
The award involves sub-grants to Brigham & Women's Hospital and Boston University to support data access, analyses, and collaborative research activities. This multi-institutional effort aims to lay the groundwork for identifying strategies to reduce fibroid incidence, particularly among Black women.