This $153,000 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to Texas Tech University Health Sciences Center (TTUHSC) aims to develop an anti-cancer approach through a novel pathway of translational regulation. The central focus is on controlling expression of the STAT3 transcription factor, which is upregulated in many tumor types and contributes to cancer progression.
The key objectives are to: 1) Identify novel STAT3 translational partners during its synthesis on the ribosome, and 2) Test the hypothesis that RAPP translational regulators can be modulated to decrease STAT3 expression and cancer cell proliferation. The research leverages unique technologies like photo-crosslinking and IPINCH to detect and characterize STAT3 regulatory mechanisms. If successful, this project could lay the foundation for future animal studies and development of new anti-cancer therapies targeting STAT3 translational control.
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