This $456,103 Project Grant awarded by the National Cancer Institute under the Cancer Biology Research (CFDA 93.396) program will fund research to enhance early detection and understand the complex interplay of genetic, social, and environmental factors contributing to endometrial cancer (EC) risk, with a focus on addressing disparities in EC outcomes among different racial and ethnic groups. The key objectives are to: 1) determine the burden of rare germline pathogenic variation associated with EC risk in racially and ethnically diverse case control cohorts, providing new insights into the genetic factors influencing EC, especially in underrepresented populations; and 2) create advanced risk models that integrate genetic and non-genetic factors (e.g. BMI, diabetes, PCOS) into comprehensive predictive models, offering personalized risk assessment tools for EC. This project aims to revolutionize EC screening and prevention strategies to make them more effective and accessible across diverse populations, addressing a significant public health concern.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $456.1k | 9/2/24 |