Project Grant R01CA298327
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a $593,557 Project Grant on March 18, 2026, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to support research through February 28, 2031. This grant funds the development of novel magnetic resonance (MR) methods to enable real-time measurement and control of BPM31510, an emerging lipophilic tumor therapy composed of Coenzyme Q10 incorporated into a lipid...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $368,294 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025 through August 31, 2028. This award supports the development of next-generation platforms for interrogating T cell receptor (TCR) specificity to identify and detect tumor antigens at the protein level. The project addresses a critical bottleneck in cancer...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a Project Grant of $119,172.00 under the Cancer Research Manpower program (CFDA 93.398) to support research addressing therapeutic response in non-small cell lung cancer (NSCLC). The project, initiated August 1, 2025, and completing July 31, 2027, focuses on developing computational approaches to integrate multi-modal and multi-omics biomedical datasets for improved...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $584,521 Project Grant on August 8, 2025, under the Cancer Treatment Research program (CFDA 93.395) to investigate subclonal determinants of radiation response in soft tissue sarcomas. The research will deliver three primary products: (1) identification and validation of epigenetic changes, including DNA methylation and chromatin accessibility alterations, that confer radioresistance to...
- Federal Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded The Leland Stanford Junior University a Project Grant of $661,135 on June 1, 2026, with a completion date of May 31, 2029. The award supports research conducted in Palo Alto, California, led by principal investigators Crabtree, Kay, Gray, and Woyach to develop novel therapeutic approaches for chronic lymphocytic leukemia (CLL), particularly for patients with disease that has become...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a $395,973 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on June 9, 2026, with performance completion targeted for May 31, 2028. The award funds development and validation of an augmented reality (AR) surgical guidance system designed to improve breast cancer lumpectomy outcomes by projecting volumetric magnetic resonance imaging (MRI) data...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $137,266 to The Leland Stanford Junior University, effective July 1, 2026 through June 30, 2028, under the Cancer Research Manpower program (CFDA 93.398). This award supports research aimed at developing comprehensive profiling methodologies for T-cell lymphoma (TCL) tumors and tumor immunity to enable personalized therapeutic interventions. The project integrates advanced molecular and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $337,739 to The Leland Stanford Junior University, effective July 1, 2025, through June 30, 2027, under the Cancer Research Manpower program (CFDA 93.398). This award supports the development and application of a novel molecular methodology for mapping intercellular protein trafficking in glioblastoma (GBM), the most common and aggressive primary brain tumor in adults. The research deliverables...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a $158,499 Project Grant under the Cancer Research Manpower program (CFDA 93.398) on May 15, 2026, with completion targeted for April 30, 2028. This award supports investigator-initiated cancer research focused on investigating the role of CDKN2A in lung adenocarcinoma metastasis. The research employs CRISPR-Cas9 somatic genome editing and tumor barcoding technologies to develop and...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a Project Grant totaling $357,370 (awarded May 5, 2026; completion date April 30, 2031) under the Cancer Treatment Research program (CFDA 93.395) to conduct research on reprogramming inflammatory fibroblasts to overcome therapeutic resistance in pancreatic ductal adenocarcinoma (PDAC). The research will investigate cancer-associated fibroblasts (CAFs), specifically a unique...
The National Cancer Institute awarded The Leland Stanford Junior University a Project Grant totaling $644,703 (awarded July 1, 2026, with completion anticipated June 30, 2031) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to develop an advanced bone marrow organoid (BMO) culture system for acute myeloid leukemia (AML) research. The project delivers a human bone marrow organoid culture methodology that preserves the native bone marrow microenvironment—including osteoid, vascular, and mesenchymal niche components—enabling long-term cultivation and study of both normal and leukemic hematopoietic cells. This air-liquid interface (ALI) primary BMO system addresses a historic limitation in hematopoietic stem cell (HSC) culture by maintaining functional hematopoiesis for extended periods (exceeding 60 days in initial testing) and supporting successful ex vivo expansion of human AML blasts from patient-derived xenografts and primary bone marrow biopsies while preserving disease histology, surface markers, and mutations. The project directly supports the Cancer Detection and Diagnosis Research Program's objectives to develop innovative diagnostic and research technologies for cancer by providing a versatile tool for fundamental investigation and therapeutic development of hematopoietic pathologies. The BMO platform demonstrates potential for transplantation studies and preclinical drug testing, addressing the program's emphasis on methods that predict disease course and response to therapy. By providing researchers with an improved ex vivo culture system that more accurately recapitulates physiological bone marrow conditions than existing methods, this grant delivers methodological advances applicable to both basic research and translational leukemia studies at Stanford's Palo Alto, California research facility.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $644.7k | 6/16/26 |