Project Grant R01AR085595
- The federal Project Grant award of $649,391 provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to enhance healing after injury. The overarching objective is to define the mechanisms that restrain tissue regeneration in order to develop new therapeutics to improve healing of the gut and skin following injury or infection. The 5-year project, which...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $413,655 on August 1, 2025 to Arizona State University (ASU) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will fund research to develop biomaterials with temporal control of proteins, such as Bone Morphogenetic Proteins (BMPs), to enhance bone repair. The research aims to mimic natural extracellular matrix interactions and synergies...
- This federal Project Grant award of $1,948,116.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research into post-transcriptional regulation of gene expression during bone regeneration, with a focus on understanding the expression patterns and biological functions of the protein Proteoglycan 4 (PRG4) during fracture healing. The research...
- This Project Grant award of $169,344 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research at the University of California, Davis to investigate the role of inflammation and immunomodulation in fracture healing in the context of polytrauma. The key objectives are to: (1) characterize the upregulation of inflammatory cytokines and innate...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $2,070,827 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to the Icahn School of Medicine at Mount Sinai. This grant aims to identify novel microbial factors that can enhance wound repair, a significant public health issue with over 100 million new acute skin wounds annually and substantial treatment costs exceeding $25 billion. The...
- This $219,609 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is aimed at developing a method to assess mechanical failure of bone matrix using in vitro cell culture. The primary goal is to overcome the current challenge of requiring whole mouse bone specimens to detect changes in bone matrix mechanical properties, by using micropillars generated from...
- This Project Grant award of $458,907 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846) aims to investigate the use of the gut microbiome to treat skeletal muscle atrophy. The research will focus on determining if cecal microbial transplant from exercise-trained mice can attenuate muscle atrophy in mice undergoing hind limb immobilization. Metagenomic and metabolomic analyses...
- The University of Delaware was awarded a $601,120 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of this 5-year study is to validate next-generation methods for diagnosing and predicting bone fracture healing, using an ovine (sheep) tibial osteotomy model. The research will employ ultrashort echo time magnetic resonance imaging...
- This $465,663 Project Grant was awarded on May 6, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research to optimize the bone surface targeting of therapeutic antibodies for the treatment of osteoporosis, a common bone disease affecting 10 million U.S. adults. The project aims to increase the local concentration and efficacy of osteoporosis...
- This $162,500 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to generate preliminary data on the relationships between mechanical loading, zinc homeostasis, and bone fracture healing. The award recipient, The Trustees of the University of Pennsylvania, will conduct in vivo studies using a rat femoral osteotomy model to investigate how the...
This $663,901 Project Grant was awarded on September 1, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports Emory University's research to understand how the gut microbiome and T-cells influence fracture healing. The project aims to investigate how gut bacteria and immune cells, particularly Th17 cells, can be leveraged to improve fracture repair and reduce complications like delayed unions and non-unions. Key aspects include examining the role of segmented filamentous bacteria in stimulating Th17 cells, and exploring the potential of live microbial biotherapeutics to enhance fracture healing. The research will be conducted at Emory University in Atlanta, GA over the award period ending on July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $663.9k | 8/25/25 |