Project Grant R01AR085071
- The federal Project Grant award of $649,391 provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to enhance healing after injury. The overarching objective is to define the mechanisms that restrain tissue regeneration in order to develop new therapeutics to improve healing of the gut and skin following injury or infection. The 5-year project, which...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $413,655 on August 1, 2025 to Arizona State University (ASU) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will fund research to develop biomaterials with temporal control of proteins, such as Bone Morphogenetic Proteins (BMPs), to enhance bone repair. The research aims to mimic natural extracellular matrix interactions and synergies...
- The University of Pennsylvania was awarded a $459,820 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant will support research into the role of mitochondrial respiration and bioenergetic metabolism in the regulation and development of growth plate chondrocytes, which are central to bone formation. The research aims to improve...
- This $663,901 Project Grant was awarded on September 1, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports Emory University's research to understand how the gut microbiome and T-cells influence fracture healing. The project aims to investigate how gut bacteria and immune cells, particularly Th17 cells, can be leveraged to improve fracture repair and...
- This Project Grant award of $454,050.00, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund the development of a novel gene therapy for bone healing. The award recipient, Mayo Clinic, will use adeno-associated virus (AAV) to deliver bone morphogenetic protein-2 (BMP-2) to critical-sized bone defects in a validated rat model. The goal is to create an...
- This $177,000 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program, supports research to investigate genetic determinants of chondrocyte maturation and its impact on skeletal growth disorders. The research at Boston Children's Hospital, a premier pediatric medical research institution, leverages a high-throughput screening approach to identify novel...
- This $162,500 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to generate preliminary data on the relationships between mechanical loading, zinc homeostasis, and bone fracture healing. The award recipient, The Trustees of the University of Pennsylvania, will conduct in vivo studies using a rat femoral osteotomy model to investigate how the...
- This Project Grant award of $169,344 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research at the University of California, Davis to investigate the role of inflammation and immunomodulation in fracture healing in the context of polytrauma. The key objectives are to: (1) characterize the upregulation of inflammatory cytokines and innate...
- The federal Project Grant award of $426,889.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the molecular regulatory mechanisms of a cartilage-enriched G-protein coupled receptor (GPCR) named ADGRG6 and its role in maintaining joint and cartilage homeostasis. The project, awarded to the University of Southern California, aims to investigate the...
- This federal Project Grant award of $570,174 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports the development and evaluation of a zonal-specific mineralized scaffold optimal for osteochondral (OC) tissue regeneration. The research aims to mimic the hierarchical microstructure and composition of native OC tissue, which consists of articular cartilage and subchondral...
This federal Project Grant award of $1,948,116.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research into post-transcriptional regulation of gene expression during bone regeneration, with a focus on understanding the expression patterns and biological functions of the protein Proteoglycan 4 (PRG4) during fracture healing. The research will be conducted by Pennsylvania State University's Milton S. Hershey Medical Center, a leader in biomedical research and medical innovation, over the project period from September 1, 2025 to August 31, 2028. The findings from this study have the potential to inform the development of novel therapeutic approaches for improving bone regeneration and healing.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 8/29/25 |