Project Grant R21AR085253
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $413,655 on August 1, 2025 to Arizona State University (ASU) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will fund research to develop biomaterials with temporal control of proteins, such as Bone Morphogenetic Proteins (BMPs), to enhance bone repair. The research aims to mimic natural extracellular matrix interactions and synergies...
- This $667,125 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), aims to develop a long-lasting, bone-targeted gene therapy for Osteogenesis Imperfecta (OI), the most common bone fragility disease. The University of Massachusetts Medical School (UMMS) will use a novel recombinant adeno-associated virus (rAAV) vector with bone-specific...
- This $430,152 Project Grant was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports the development of a stand-alone simulation platform for designing tissue engineering scaffolds to serve as bone graft substitutes. The platform will leverage COMSOL software and JMP statistical design functionality to optimize the architecture and composition of...
- This $663,901 Project Grant was awarded on September 1, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports Emory University's research to understand how the gut microbiome and T-cells influence fracture healing. The project aims to investigate how gut bacteria and immune cells, particularly Th17 cells, can be leveraged to improve fracture repair and...
- This Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports research to understand how human bone tissue dynamically adapts at the nanoscale level under various loading conditions. The $719,538 award to the Trustees of the University of Pennsylvania, made on May 1, 2024, will investigate the real-time rearrangement and deformation of the nanoscale components of healthy and osteoporotic bone tissue when subjected to cyclic loading....
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $703,634 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Regents of the University of California, San Francisco (UCSF). The grant, awarded on August 15, 2025, will fund a study to develop and validate age-relative measures of biochemical intervertebral disc health. The research aims to discover the age-course of biochemical disc composition,...
- This $162,500 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to generate preliminary data on the relationships between mechanical loading, zinc homeostasis, and bone fracture healing. The award recipient, The Trustees of the University of Pennsylvania, will conduct in vivo studies using a rat femoral osteotomy model to investigate how the...
- This federal Project Grant award of $685,866.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The goal of this 5-year project is to leverage context-specific expression quantitative trait loci (eQTLs) to identify potential causal genes underlying genome-wide association study (GWAS) findings related to bone mineral density (BMD) and...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is developing the X-Visual, a sensor to track fracture healing in cannulated screws used for hip fracture fixation. The $299,999 award to Aravis Biotech LLC will cover the design, computational modeling, and initial testing of this innovative device that can non-invasively measure screw bending...
- The University of Delaware was awarded a $601,120 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of this 5-year study is to validate next-generation methods for diagnosing and predicting bone fracture healing, using an ovine (sheep) tibial osteotomy model. The research will employ ultrashort echo time magnetic resonance imaging...
This $219,609 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is aimed at developing a method to assess mechanical failure of bone matrix using in vitro cell culture. The primary goal is to overcome the current challenge of requiring whole mouse bone specimens to detect changes in bone matrix mechanical properties, by using micropillars generated from bony nodules formed in vitro to evaluate bone fracture toughness and strength. The project will establish the use of this micropillar technique in the context of deficiency of the G protein Gs, which is known to cause severe bone fragility. This 2-year award to the University of California, San Francisco will run from September 2025 through August 2027 and aims to provide a more efficient in vitro approach to screening for factors that influence bone matrix mechanical properties, which is a critical determinant of bone fragility and fracture risk.