Project Grant R01AR083052
- The National Science Foundation (NSF) Office of International Science and Engineering (CFDA 47.079) awarded a $420,000 Project Grant to Lehigh University to develop predictive computer simulation tools that can forecast bone healing progress for patients with poorly healing fractures. The 4-year project, running from October 1, 2025 to September 30, 2029, aims to create digital twin models of real bones using medical imaging data. These simulations will provide insights into individual healing...
- This $162,500 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to generate preliminary data on the relationships between mechanical loading, zinc homeostasis, and bone fracture healing. The award recipient, The Trustees of the University of Pennsylvania, will conduct in vivo studies using a rat femoral osteotomy model to investigate how the...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is developing the X-Visual, a sensor to track fracture healing in cannulated screws used for hip fracture fixation. The $299,999 award to Aravis Biotech LLC will cover the design, computational modeling, and initial testing of this innovative device that can non-invasively measure screw bending...
- This $663,901 Project Grant was awarded on September 1, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports Emory University's research to understand how the gut microbiome and T-cells influence fracture healing. The project aims to investigate how gut bacteria and immune cells, particularly Th17 cells, can be leveraged to improve fracture repair and...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to advance the understanding of muscle-subtendon units and their role in Achilles tendinopathy. The $666,825 award to the University of Delaware will fund a 5-year research study using advanced in vivo techniques such as MRI, ultrasound, and biomechanical assessments. The key objectives are...
- This federal Project Grant award of $306,722 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funding supports Penderia Technologies Inc., a small business joint venture located in Eugene, Oregon, to fabricate and characterize a distal femoral fracture fixation plate that features an implantable, battery-free, wireless sensor. This sensor will enable...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $413,655 on August 1, 2025 to Arizona State University (ASU) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will fund research to develop biomaterials with temporal control of proteins, such as Bone Morphogenetic Proteins (BMPs), to enhance bone repair. The research aims to mimic natural extracellular matrix interactions and synergies...
- This federal Project Grant award of $1,948,116.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research into post-transcriptional regulation of gene expression during bone regeneration, with a focus on understanding the expression patterns and biological functions of the protein Proteoglycan 4 (PRG4) during fracture healing. The research...
- This $219,609 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is aimed at developing a method to assess mechanical failure of bone matrix using in vitro cell culture. The primary goal is to overcome the current challenge of requiring whole mouse bone specimens to detect changes in bone matrix mechanical properties, by using micropillars generated from...
- This $667,125 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), aims to develop a long-lasting, bone-targeted gene therapy for Osteogenesis Imperfecta (OI), the most common bone fragility disease. The University of Massachusetts Medical School (UMMS) will use a novel recombinant adeno-associated virus (rAAV) vector with bone-specific...
The University of Delaware was awarded a $601,120 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The purpose of this 5-year study is to validate next-generation methods for diagnosing and predicting bone fracture healing, using an ovine (sheep) tibial osteotomy model. The research will employ ultrashort echo time magnetic resonance imaging (UTE-MRI) and finite element analysis-based virtual mechanical testing to quantify and predict the structural quality of bone healing. The study aims to establish UTE-MRI assessment of callus mechanical properties, predict late-stage fracture healing from early MRI scans, and deploy the MRI-based virtual mechanical testing approach for broader applications. This research aims to address the lack of reliable biomarkers to detect problems with bone healing early, which represents a major barrier to improving patient care for the approximately 9.6 million Americans affected by bone fractures each year.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $601.1k | 9/24/25 |