This Project Grant award, totaling $588,302, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research project aims to investigate the role of glutamine metabolism in regulating osteoclast differentiation and bone resorption, as well as evaluate the efficacy of a glutaminase inhibitor in mitigating bone loss in an osteoporosis mouse model. Key aspects...
This Project Grant award in the amount of $375,100.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award will fund a two-year research study at the Regents of the University of Minnesota focused on identifying myeloid progenitors that help maintain cortical bone with age, and characterizing cells and molecules that promote coupling within cortical...
The Project Grant award of $1,175,680, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to comparatively assess the therapeutic potential of combined anabolic therapy versus the current standard-of-care single-drug approach in postmenopausal women at high risk of fragility fracture. Specifically, the study will test the hypothesis that in...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will provide $652,729 to the Van Andel Research Institute (VAI) in Grand Rapids, Michigan to investigate the mechanisms by which the X-linked chromatin modifying enzyme KDM5C regulates bone mass in females. The research aims to define how loss of KDM5C affects osteoclast function,...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to support research into molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis under pathological inflammatory conditions. The research aims to elucidate how inflammation, particularly in the context of orthopedic periprosthetic...
This $313,000 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will fund research by Emory University to establish phosphorylated WNT5A produced by osteoclasts as a potential anabolic bone drug. The research aims to determine how osteoclast-derived phospho-WNT5A can enhance bone formation in vivo and elucidate the cellular and molecular mechanisms by...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $220,224 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Regents of the University of Colorado (CU) to develop "Granular Hydrogels for the Controlled Delivery of Immunomodulatory and Angiogenic Extracellular Vesicles to Enhance Bone Tissue Regeneration." This 3-year project, with a period of performance from Jul 4, 2024 to Aug 31,...
This federal Project Grant award, valued at $783,176.00 and issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop and clinically validate a comprehensive bone quality assessment technique using photon-counting detector CT (PCD-CT) imaging. The research project, titled "Comprehensive Assessment of Bone Quality Using Clinical Photon-Counting Detector...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $219,605 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the Regents of the University of Michigan. The grant supports research to identify the role of the mechanosensitive ion channel PIEZO1 in mediating canonical Wnt/β-catenin signaling and driving pro-inflammatory and pro-fibrotic phenotypes in synovial fibroblasts, which contribute to...
This Project Grant award, valued at $483,070.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research to investigate the dynamic mechanisms of bone extracellular matrix (ECM) assembly and resorption, and how these processes are integrated with osteogenic cellular dynamics and differentiation. Key aims include using advanced live-cell...