Project Grant R01AR084027

Award Date 8/16/24
Completion Date 7/31/29
Dollars Obligated $844K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
Irvine, CA 92697, USA
Similar Awards
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $177,872 to the University of Houston System to study the interaction between human induced pluripotent stem cell (hiPSC)-derived endothelial cells and skeletal muscle progenitor cells, both in vitro and in vivo. The research aims to elucidate the underlying mechanisms governing the...
This $420,883 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to improve muscle regeneration and restore function following serious traumatic injuries. The University of Missouri System, the prime recipient, will leverage its expertise in microvascular imaging, muscle biology, and biomaterials to investigate the role of fibroadipogenic...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the novel role of HOX-expressing interstitial cells in muscle growth, homeostasis, and regeneration. The $557,357 award, effective March 14, 2025 through February 28, 2030, will be used by the University of Wisconsin-Madison to interrogate the potential of...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the functional roles of microRNA-320 (miR-320) in skeletal muscle. The $374,204 award to The Leland Stanford Junior University will fully characterize a muscle-specific miR-320 knockout mouse model, examine the underlying mechanisms of the observed muscle wasting...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $439,791.00 over a 5-year period from March 1, 2025 to February 28, 2030 to The University of Texas Southwestern Medical Center. The funding will support research to investigate the molecular mechanisms underlying myoblast fusion, which is essential for skeletal muscle development and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, CFDA 93.846) provides $248,724 to the University of Alabama at Birmingham (UAB) to conduct research on the role of cellular senescence in skeletal muscle loss and dysfunction. The overarching objectives are to (1) obtain the necessary skills and training to develop a translational research program investigating mechanisms underlying skeletal muscle wasting, and (2) generate data to...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA Program 93.846 Arthritis, Musculoskeletal and Skin Diseases Research, provides $600,475 to the University of California, Davis to develop a collagen-based scaffold modified with specific integrin ligands and placental mesenchymal stem cell-derived extracellular vesicles. This innovative fetal tissue engineering approach aims to synergistically recruit and guide endogenous...
This Project Grant award of $616,256 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop and validate a pre-clinical "intelligent biorobot" for the regenerative rehabilitation of volumetric muscle loss (VML) defects. The primary objectives are to (1) develop and optimize a cell-laden biorobot that mimics skeletal muscle and can generate electrical...
This $692,292 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the Children's Research Institute to better understand the regulation of pediatric regenerative myogenesis and its implications for muscle disease. The project aims to investigate the interplay of immune and stromal factors in the muscle niche that...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $737,528 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of California, Irvine (UCI) to conduct mechanistic and translational investigations of HSPB8-associated dominant rimmed vacuolar myopathy. The research aims to investigate the molecular pathogenesis of this rare genetic muscle disorder, reverse the mutant HSPB8 pathology using an autophagy...

This $843,630 Project Grant, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research at the University of California, Irvine to improve skeletal muscle regeneration using human pluripotent stem cell (hPSC) transplantation therapies.

The project aims to investigate how hPSCs can be directed to functionally mature muscle cells, and how the stem cell niche can be modulated to better support and maintain hPSC-derived muscle progenitor cells. Key activities include using lineage tracing and genetic inhibition to understand myogenesis from hPSCs, building simplified in vitro niche models to support hPSC-derived muscle cells, and leveraging a mouse model to study niche formation and the function of key niche factors in vivo. The overall goal is to shed new light on hPSC-derived muscle maturation and identify strategies to improve the regenerative capacity of transplanted muscle stem cells.

Generated 8/5/25, 2:43 AM