The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $820,142 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Miami University. The project aims to investigate the effects of early-life physical inactivity in mice on muscle quality, function, and frailty in adulthood. Specifically, the research will examine how different levels of physical inactivity during a key postnatal development period impact...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $215,600 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Baylor University. The project aims to utilize senolytic compounds to reduce cellular senescence and enhance the response to exercise in mice with cancer cachexia induced by the chemotherapy drug cisplatin. The research will pursue three specific aims: 1) determine if senescent cell removal...
This $557,357 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into a novel subset of muscle progenitor cells expressing Hox genes. The primary focus is to interrogate the potential of these Hox-expressing interstitial cells to contribute to muscle growth, homeostasis, and regeneration using in vivo and in vitro approaches. Key...
This $540,021 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The goal of the project is to characterize the functional role of the dual-specificity phosphatase DUSP4 in regulating skeletal muscle size and strength. Through in vivo experiments in mouse models, the research aims to determine if DUSP4 expression is necessary and sufficient to induce muscle atrophy, and to identify the...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is providing $473,377 to the University of California, Irvine to conduct research on modulating the stem cell niche to improve skeletal muscle regeneration. The research aims to interrogate how muscle cells arise and develop from human pluripotent stem cells, build simplified in vitro niches...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the molecular mechanisms responsible for sarcopenia, the loss of muscle mass and function associated with aging. The $576,893 award to the University of Texas Medical Branch at Galveston will test the hypothesis that post-translational modifications of the myosin protein and its chaperone UNC-45 contribute to the diminished muscle function observed in elderly populations....
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $485,375 to the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The overall goal is to better understand the molecular mechanisms underlying age-related decline in muscle function, with the potential to help prevent or slow down this process. Specifically, the project will: 1) Explore if alternative splicing of mRNA results in...
This Project Grant award of $522,714.00, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the mechanisms behind skeletal muscle endurance and stretch activation. The research aims to: Test the hypothesis that stretch activation is an alternative mechanism to maintain force production and contribute to skeletal muscle endurance. This will...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $374,204 to The Leland Stanford Junior University to investigate the functional roles of microRNA-320 in skeletal muscle. The research aims to: 1) Characterize the phenotype of a muscle-specific microRNA-320 knockout mouse model, 2) Investigate the underlying molecular mechanisms for the...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $151,471 to the University of California, Davis to investigate the use of collagenase to target collagen architecture in fibrotic skeletal muscle. The goal is to reduce muscle stiffness and promote tissue regeneration, with a focus on the extracellular matrix changes seen in Duchenne...