This Project Grant award of $473,377 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports research to modulate the stem cell niche and improve skeletal muscle regeneration. The key objectives are to: Interrogate how muscle cells arise and develop functional characteristics from human pluripotent stem cells (hPSCs) through analysis of myogenic commitment factors and inhibition of...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $557,357 to the University of Wisconsin System to study the role of HOX-expressing interstitial cells in skeletal muscle growth, homeostasis, and regeneration. The research aims to interrogate the potential of these cells to contribute to muscle development and repair, with the goal...
This federal Project Grant award of $201,960 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to define the functional roles of different isoforms of the myosin-binding protein C (MyBP-C) in skeletal muscle. The University of Vermont & State Agricultural College, the grant recipient, will use the "designer MyBP-C" zebrafish model system...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the functional roles of microRNA-320 (miR-320) in skeletal muscle. The $374,204 award to The Leland Stanford Junior University will fully characterize a muscle-specific miR-320 knockout mouse model, examine the underlying mechanisms of the observed muscle wasting...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $488,575.00 to the University of Arizona to conduct research on the structure and function of myosin binding protein-C (MyBP-C) in skeletal muscles. The goal is to understand how MyBP-C regulates skeletal muscle contraction and how mutations in the genes encoding slow and fast MyBP-C...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research", provides $926,078 to The Ohio State University to conduct research on the role of autoantibodies against membrane repair proteins in the pathogenesis of idiopathic inflammatory myopathies (IIM), a group of inflammatory muscle disorders. The research aims to: 1) define the mechanistic role of...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $525,048 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Children's Hospital Medical Center in Cincinnati, OH. The grant is titled "Development and Optimization of Skeletal Muscle Delivery Vehicles" and runs from July 8, 2024 to May 31, 2029. The project aims to develop novel gene therapy delivery vehicles, including lentiviruses and extracellular vesicles,...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the use of collagenase to target collagen architecture in fibrotic skeletal muscle to reduce stiffness and promote tissue regeneration. The $151,471 award, granted to the University of California, Davis from September 2024 to April 2026, will fund experiments to elucidate the...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop specialized cryo-electron microscopy (cryo-EM) techniques to study the structures of mitochondrial complexes implicated in muscular myopathies. The $444,109 award to the Scripps Research Institute in La Jolla, CA will support the creation of methods to directly visualize endogenous...
This $216,113 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to target the GDF15-GFRAL signaling pathway in a mouse model of mitochondrial myopathy. The research aims to prevent and treat the cachexia (muscle wasting) associated with this condition by inhibiting the GDF15-GFRAL signaling pathway using established antibodies. The...