This Project Grant award of $1,517,519 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research program) supports research to identify the upstream drivers of type I interferon production in systemic lupus erythematosus (SLE). The project, titled "Upstream Drivers of Type I Interferons in Lupus", focuses on understanding the molecular mechanisms by which innate immune cells, such as neutrophils and monocytes, and skin cells trigger the chronic overproduction of type I interferons that contributes to SLE disease pathogenesis. The research will leverage cutting-edge technologies, patient samples, and collaborative expertise across three principal investigators to address key knowledge gaps. Specifically, the award aims to: 1) identify the nucleic acid species that activate interferon-stimulating pathways in SLE neutrophils and monocytes, and 2) characterize the pathogenic DNA species and associated sensors driving increased interferon production in the skin of SLE patients, particularly in response to ultraviolet light exposure. The project includes sub-awards to Rockefeller University and the University of Michigan to provide specialized expertise and resources in areas such as ultrasensitive protein detection and protein-bound nucleic acid sequencing.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $75.8k | 9/3/24 | ||
| Not listed | $720.8k | 5/28/24 | ||
| Not listed | $720.8k | 5/28/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
UWSC15803S | Rockefeller University | Project Grant R01AI186337 | $219.7k | 11/13/24 | |
UWSC15802S | Regents Of The University Of Michigan | Project Grant R01AI186337 | $219.7k | 11/4/24 |