Project Grant R01AI183676
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,364,935 to the Oklahoma Medical Research Foundation (OMRF) to conduct research on the molecular mechanisms underlying systemic lupus erythematosus (SLE). The research focuses on understanding the role of autophagy, a cellular process, in the immune dysregulation and organ damage observed in SLE. The...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,430,679 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the Oklahoma Medical Research Foundation (OMRF) to investigate the mechanisms by which a specific genetic variant of the IFIH1 protein contributes to the development of systemic lupus erythematosus (SLE). The project aims to: 1) examine how the IFIH1 risk variant enhances inflammation, 2) determine if it...
- This $256,808 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to better define the molecular mechanisms that cause and perpetuate systemic lupus erythematosus (SLE). The research aims to expand analysis of altered mRNA splicing in SLE neutrophils and explore the consequences of these alterations, including the potential generation of novel autoantigens. Key objectives include determining...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $700,000 in funding to the University of Oklahoma Health Sciences Center from September 2025 to August 2029. The award supports research to define the genes and epigenetic regions directly regulated by the ARID3A protein, and determine how ARID3A contributes to the functions associated with tolerance breaches in...
- The U.S. Defense Health Agency awarded a $999,999.00 Project Grant to the Oklahoma Medical Research Foundation (OMRF) under the Military Medical Research and Development (CFDA 12.420) federal grant program. The award, titled "ELUCIDATING THE IMPACT OF IFIH1 DURING SYSTEMIC LUPUS ERYTHEMATOSUS," will fund research on understanding the role of IFIH1 in systemic lupus erythematosus (SLE) over a performance period from May 1, 2025 to April 30, 2028. OMRF, a non-profit biomedical research...
- This $216,113 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to characterize impairment of hematopoietic stem cells (HSCs) and their role in the hematological abnormalities associated with systemic autoimmune diseases like systemic lupus erythematosus (SLE). The research aims to elucidate the cell-extrinsic factors and epigenetic...
- This Project Grant award, valued at $704,424.00 and funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research to identify rare pathogenic genetic variants and their functional consequences in Systemic Lupus Erythematosus (SLE), a chronic autoimmune disease. The research will apply whole genome sequencing on 127 SLE families and patients, define polygenic risk scores, and identify novel pathogenic coding and non-coding variants, with the goal...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $778,266 Project Grant to the Oklahoma Medical Research Foundation (OMRF) to conduct research on sarcoidosis susceptibility and disease burden. The project aims to apply a multi-omic approach to distinguish sarcoidosis patients from healthy and other disease controls, identify biomarkers for high disease burden, and elucidate the mechanisms underlying the development...
- This Project Grant award of $405,350.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to characterize lipid droplets in macrophage subsets and determine if manipulating lipid droplet content can shift macrophage function, with the goal of uncovering new therapeutic targets for systemic lupus erythematosus (SLE). The award recipient is The...
- This Project Grant award of $300,000.00, provided by the Department of Health and Human Services' National Institutes of Health under the Trans-NIH Research Support program (CFDA 93.310), supports research at Brigham & Women's Hospital in Boston, MA to investigate the role of activated neutrophils and self-reactive T cells in the pathogenesis of systemic lupus erythematosus (SLE). The research aims to understand how immune cell abnormalities, specifically the interaction of immune...
This $793,093 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to define the regulatory landscape of systemic lupus erythematosus (SLE) and its cardiovascular disease (CVD) comorbidity. The grantee, Oklahoma Medical Research Foundation, will conduct systematic, high-throughput studies in macrophages derived from induced pluripotent stem cells to identify genetic variants that disrupt regulatory elements and target genes involved in macrophage biology, potentially fueling both SLE and CVD. The project includes sub-award work with the University of California, San Diego to assist with bioinformatics, molecular modeling, and interpreting experimental results on potential regulatory variants and their target genes. The goal is to uncover genetic factors contributing to the interplay between SLE and CVD, which may inform targeted therapies or drug repurposing strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $793.1k | 11/20/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
0395UCSDLLS | University Of California, San Diego | Project Grant R01AI183676 | $18.5k | 1/20/25 |