Project Grant P01AI172523
- This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $115,414 to the Beckman Research Institute of the City of Hope to conduct research aimed at concurrently eradicating pathogenic plasma cells and their precursors in systemic lupus erythematosus (SLE). The award, which runs from September 2024 to August 2026, will support two specific aims: 1) determining the effect of knockdown of the...
- This Project Grant award of $558,045.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate how the protein phosphatase 2A (PP2A) enzyme controls the function of T cells and metabolic enzymes, and the impact on regulatory T cells (Tregs) and inflammation in systemic lupus erythematosus (SLE). The research will use mouse models with conditional PP2A or pentose phosphate...
- This $256,808 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to better define the molecular mechanisms that cause and perpetuate systemic lupus erythematosus (SLE). The University of Washington is conducting this research, which focuses on analyzing altered mRNA splicing in SLE neutrophils and exploring the consequences of these splicing changes, including...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $3,364,935 Project Grant to the Oklahoma Medical Research Foundation (OMRF) to conduct research on the functional and mechanistic characterization of lupus susceptibility. The award period runs from September 3, 2025 to August 31, 2029. The research focuses on understanding the role of autophagy, a cellular mechanism, in the...
- This federal Project Grant award of $2,989,958 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to investigate the role of pyrimidine metabolism in the development of autoreactive B cells and systemic lupus erythematosus (SLE). The research, conducted by Thomas Jefferson University's Sidney Kimmel Medical College, aims to delineate the mechanisms by which pyrimidine synthesis...
- This Project Grant award of $300,000.00 from the Trans-NIH Research Support program (CFDA 93.310) under the Department of Health and Human Services National Institutes of Health (NIH) was provided to Brigham & Women's Hospital Inc. to investigate the role of neutrophils and T cells in the development of systemic lupus erythematosus (SLE), lupus nephritis, and vasculitis. The research aims to elucidate how immune cell abnormalities, including the activation of neutrophils and self-reactive...
- The University of California, San Francisco will conduct research on NR4A family proteins as markers and mediators of B cell tolerance in systemic lupus erythematosus (SLE) under a three-year, $738,631 Project Grant from the Department of the Army Medical Command. The grant is part of the Military Medical Research and Development program administered by the Department of Defense and aims to transform military and public health through innovative medical research solutions for battlefield...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $216,113.00 to New York University School of Medicine to investigate the mechanisms behind hematological abnormalities associated with systemic autoimmune diseases like systemic lupus erythematosus (SLE). The research aims to characterize impairments in hematopoietic stem cells that...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $423,500 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to Loyola University of Chicago's Health Sciences Campus. The funding supports research to develop novel antibodies that target autoreactive B cells as a potential therapeutic for systemic lupus erythematosus (SLE) patients, with a focus on the underserved African American population. The research aims to determine the...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $637,018 to Rutgers, The State University of New Jersey to investigate the role of natural killer (NK) cells in regulating humoral immune responses during systemic lupus erythematosus (SLE or lupus). The research aims to dissect the effects of NK cell, T follicular helper (Tfh)...
LEARNING FROM REMISSION AND RELAPSE IN SLE - ABSTRACT - OVERVIEW THIS PROGRAM PROJECT IS AN EXPLORATION OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS WHO ARE IN LONG TERM CLINICAL REMISSION ON NO CORTICOSTEROID OR IMMUNOSUPPRESSIVE MEDICATION. WE WILL STUDY BLOOD IMMUNE CELLS AT THE SINGLE CELL LEVEL EXPLORING DISTRIBUTION OF CELLULAR SUBSETS AND TRANSCRIPTIONAL, EPIGENETIC AND PROTEOMIC PROFILES, AS WELL AS THE REPERTOIRE OF NAIVE AND MEMORY B CELLS REACTIVE WITH NUCLEAR ANTIGENS. WE WILL EXPLORE BRAIN FUNCTION IN THESE PATIENTS TO DETERMINE IF THERE IS ONGOING INFLAMMATION IN THE CENTRAL NERVOUS SYSTEM IN SOME PATIENTS DESPITE A LACK OF INFLAMMATION IN THE PERIPHERY. GIVEN THE NOW RECOGNIZED INTERPLAY OF THE IMMUNE SYSTEM AND THE BRAIN, WE WILL SEEK CORRELATIONS BETWEEN IMMUNE CELL PROFILE AND BRAIN FUNCTION. AS APPROXIMATELY 25% OF PATIENTS IN REMISSION CAN BE EXPECTED TO RELAPSE OVER 5 YEARS, WE WILL SEEK PREDICTORS OF RELAPSE. THESE STUDIES SHOULD TEACH US ABOUT PATIENT HETEROGENEITY, NOVEL STATES OF IMMUNE OR BRAIN HOMEOSTASIS, AND PREDICTORS OF SUSTAINED REMISSION OR FLARE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $90.9k | 9/11/25 | ||
| Not listed | $133.0k | 9/10/25 | ||
| Not listed | $2.7m | 8/28/25 | ||
| Not listed | $2.9m | 5/9/24 |