The federal Project Grant award R21AI183127, totaling $423,500.00, was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The primary goal of this 2-year award to Loyola University of Chicago is to develop novel antibodies that specifically target autoreactive B cells as a potential therapeutic approach for treating systemic lupus erythematosus (SLE), particularly in African American patients...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,504,456 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Chicago. The 5-year grant, awarded on August 15, 2024, will support research using artificial intelligence to bridge human and murine studies of lupus nephritis progression. Specifically, the project aims to investigate tubulointerstitial hypoxia, metabolic dysfunction, capillary rarefaction, immune...
This Project Grant award of $413,860, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to investigate the interactions between non-tuberculous mycobacteria (NTM) infections, specifically Mycobacterium abscessus (MAB), and the onset/progression of systemic lupus erythematosus (SLE). The research will utilize preclinical mouse models and ex vivo models with fetal...
This federal Project Grant award, valued at $715,957 and awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA Program 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports research to elucidate the molecular mechanisms by which interferon cytokines promote the differentiation and expansion of T peripheral helper (Tph) cells in systemic lupus erythematosus (SLE) patients. The award, with a project period from March 2025 to...
This federal Project Grant award of $558,045.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant aims to investigate how the enzyme protein phosphatase 2A (PP2A) regulates immune cell function and metabolism in the context of systemic lupus erythematosus (SLE). Key objectives include determining how PP2A controls enzymes involved in glycolysis and the pentose phosphate pathway,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a 5-year career development program for a dermatologist and physician-scientist to study the role of retroelements in systemic lupus erythematosus (SLE). The $173,556 award will enable the researcher to delineate gene and retroelement expression patterns, inflammatory cytokine levels, and retroelement-specific autoreactive CD4+ T cells in SLE...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), provides $256,808 to the University of Washington to investigate the role of dysregulated mRNA splicing in systemic lupus erythematosus (SLE). The goal is to better define the molecular mechanisms that cause and perpetuate SLE by examining altered protein structures and neoepitopes in lupus neutrophils. The research...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $709,019 to the Benaroya Research Institute at Virginia Mason in Seattle, WA to conduct research on the role of the FOXP3 isoform in regulating autoantibody production and the development of systemic lupus erythematosus (SLE). The key objectives are to: 1) determine how the FOXP3 exon 2 isoform impacts germinal...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $115,414 to the Beckman Research Institute of the City of Hope to conduct research aimed at concurrently eradicating pathogenic plasma cells and their precursors in systemic lupus erythematosus (SLE). The award, which runs from September 2024 to August 2026, will support two specific aims: 1) determining the effect of knockdown of the...
This $793,093 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to define the regulatory landscape of systemic lupus erythematosus (SLE) and its cardiovascular disease (CVD) comorbidity. The grantee, Oklahoma Medical Research Foundation, will conduct systematic, high-throughput studies in macrophages derived from induced pluripotent stem cells to identify genetic variants that disrupt regulatory...