Project Grant R01AI184441
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $639,084 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research to elucidate the functional heterogeneity of naive CD8 T cells, the precursors of effector and memory T cells that are critical for immune responses against pathogens and cancer. The 5-year project aims to provide a deeper understanding of...
- This $534,000 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of antigen location, peptide:MHCII complex density, and complex half-life as drivers of CD4+ T cell differentiation. The research, conducted by the Children's Hospital of Philadelphia, aims to provide clarity on how the strength of "Signal 1" (antigen...
- This $737,502 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research to investigate the role of the WDFY4 protein in the activation and development of regulatory T cells (Tregs). The key objectives are to: 1) Determine the impact of WDFY4 on the T cell receptor (TCR) repertoire, particularly in Tregs, to identify self-reactive TCRs dependent on WDFY4 and assess their function in vivo; 2)...
- This federal Project Grant award of $658,657, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the University of Virginia on the biophysical and functional coupling of protein condensates to ordered lipid domains in T-cells. The research aims to reveal the mechanisms by which protein condensates and membrane domains cooperatively regulate T-cell signal transduction and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $246,623 to New York University School of Medicine under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The goal of this 2-year project is to investigate the molecular mechanisms that control the tolerogenic function of dendritic cells (DCs), which play a critical role in regulating immune homeostasis and promoting tolerance. The proposed research aims to: 1) identify...
- This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the generation and regulation of TFH13 cells that drive pathogenic IgE in allergic conditions. The overarching goal is to elucidate the pathways leading to TFH13 cell differentiation, which play a critical...
- The federal Project Grant award of $3,436,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the role of the TLE3 transcription cofactor in regulating the function and persistence of CD8+ T cells during chronic viral infections and cancer. The research aims to molecularly reconstruct the T cell exhaustion process and identify therapeutic...
- This Project Grant award, valued at $264,750, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The funding supports research on the regulation of dendritic cell positioning and function in lymph nodes, with a focus on understanding how integrin-mediated mechanisms optimize antigen presentation and the generation of anti-tumor immune responses. The project explores the role...
- This federal Project Grant award, in the amount of $766,265, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to understand the role of regulatory T cells (Tregs) in promoting donor-specific transplantation tolerance, which could improve outcomes for transplant patients by eliminating the need for chronic immunosuppression. Key areas of investigation include...
- The Project Grant award of $189,376 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports research to unravel the interactions between skin microbiota and the immune system that drive early-life commensal tolerance. The research aims to better understand the mechanisms by which conserved microbial signals, specifically those recognized by Toll-like Receptor 2 (TLR2), promote the...
This federal Project Grant award of $3,147,392.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how dendritic cells initiate specific T helper (Th) cell responses to pathogens. The research aims to elucidate the innate sensing mechanisms by which dendritic cells drive the differentiation of Th1 versus Th17 lineage cells in response to distinct microbial stimuli. The project will investigate the role of the unfolded protein response (UPR) pathway in dendritic cells and its importance for generating pathogen-specific Th17 responses. This 4-year research project will be conducted by the Children's Hospital Medical Center in Cincinnati, Ohio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 8/28/25 |