This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...
This $423,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate the role of the spleen in maintaining immune tolerance to transplanted islets. The research aims to: Comprehensively profile alloreactive regulatory T cells (Tregs) and exhausted T cells in the spleens of non-human primates with tolerance to islet transplants, testing the hypothesis that sustained tolerance is...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $231,131 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Duquesne University of the Holy Spirit to develop injectable 3D-clustered human fibroblastic reticular cells (clFRCs) for expanding regulatory T cells (Tregs) to manage allograft transplant rejection. The 2-year project, running from June 2025 to May 2027, aims to optimize the clFRC prototype to generate Tregs in vitro and characterize the...
This Project Grant award of $194,740 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to characterize the development of lung-resident, self-antigen-specific regulatory T cells (Tregs) following acute lung injury. The goal is to understand how these "experienced" Tregs can promote tolerance and prevent future autoimmunity. The principal investigator, Dr. Daniel Shin at...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $210,867 to Drexel University to develop a cell-based therapy for generating donor-specific immune tolerance in kidney transplant recipients. The key products and services being delivered through this award include: Developing "push/pull particle" tolerogenic dendritic cells (PPP-TolDCs) that can be...
The University of Pittsburgh received a $679,937 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on mechanisms and therapeutic targeting of T cell regulation in heart allograft recipient monkeys. The 5-year project aims to investigate the impact of cytokine modulation and administration of novel, donor-specific chimeric antigen receptor regulatory T cells (CARTREG) on promoting long-term...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports innovative research to enhance regulatory immune cell function and extend kidney allograft survival in non-human primates. The $1,455,073 award to the University of Pittsburgh aims to develop new agents and technologies that selectively promote dendritic cell tolerogenicity and regulatory T cell function, with the goal...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $441,202 to The Regents of the University of California, Berkeley to conduct research on the role of ex-Tregs (ex-regulatory T cells) in autoimmunity and cancer immunity. The goal is to investigate whether ex-Tregs, which arise from regulatory T cells (Tregs), are required to promote anti-cancer immunity and...
This Project Grant award for $327,500 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to better understand the role of the CD43 receptor on effector CD8+ T cells during acute allograft rejection. The key objectives are to: Define the effector mechanisms that distinguish CD43+ effector T cells from CD43- effector T cells, including their differentiation pathways, trafficking...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,022,197 to the University of California, San Diego (UCSD) to study the role of regulatory T (Treg) cells and the IL-27 cytokine in maintaining intestinal immune homeostasis. The research aims to examine the molecular mechanisms driving IL-27 expression in gut Treg cells, as well as identify gut microbiome factors...