The Research Foundation for the State University of New York at Stony Brook University will conduct research from August 1, 2022 to July 31, 2025 to inhibit Powassan virus persistence and spread to neuronal compartments under a $1.9 million Project Grant from the Department of the Army Medical Command. The research is funded through the Military Medical Research and Development program (CFDA 12.420), which supports biomedical research to improve military and public health outcomes. Specifically,...
This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research program supports research to investigate how distinct age-associated B cell subsets can protect the aged from influenza. The project aims to determine the potential of different age-associated B cell subsets to respond to influenza infection and generate antibody-secreting cells, B cell memory, and long-lived...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $790,000.00 in funding to the Regents of the University of Minnesota to conduct research on the immune response to West Nile virus (WNV) and the factors that influence the development of neuroinvasive disease. The goal is to gain a molecular understanding of WNV neuroinvasion, central nervous system immunity, and the...
This $237,165 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the molecular mechanisms underlying internal ribosomal entry site (IRES)-mediated initiation of picornavirus translation. The research aims to identify factors that enable ribosomes to unwind the sequestered initiation codon in type 1 IRES structures, establish the interactions...
This three-year project grant from the National Institutes of Health's National Institute on Aging, titled "Aging Research" under the CFDA number 93.866, provides $1,797,870 to Stony Brook University to investigate the mechanisms by which aging impacts the risks of Alzheimer's and related dementias. Specifically, the awardee will test the hypothesis that age and neurodegenerative protein pathology synergize to activate retrotransposons and endogenous retroviruses, mobile genetic...
This federal Project Grant award of $238,787 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to advance the understanding of protein secretion by the ESX-1 system in mycobacteria, including pathogens like Mycobacterium tuberculosis. The research project, running from February 2025 to January 2027, will apply novel cell wall-specific protein tagging, surface-specific protein detection, and...
This $3,659,973 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of South Florida. The grant supports a multi-year research initiative to investigate the molecular mechanisms underlying the neurological sequelae, known as "Neuro-COVID," observed in some COVID-19 patients. The key objectives are to: Assess how aging exacerbates inflammation and tauopathy (abnormal tau protein buildup) following COVID-19 infection in mouse...
This $583,047 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how Rift Valley Fever Virus (RVFV) disseminates from the site of infection in the skin to the central nervous system (CNS). The project aims to establish the routes and mechanisms by which RVFV invades the CNS following peripheral exposure, using novel rodent CNS infection models...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $749,594 to study the role of the host sphingosine kinase 1 (SK1) pathway in controlling infection by the fungus Cryptococcus neoformans (CN) during immunodeficiency. The research aims to: 1) determine the immune mechanism by which SK1-S1P regulates the organization of CN granuloma, and 2) define the immune response by...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $192,500.00 to the University of South Alabama to investigate the mechanisms of central nervous system invasion by the Lyme disease pathogen, Borrelia burgdorferi. The research aims to: Determine the role of the blood-cerebrospinal fluid barrier as a site for B. burgdorferi and immune cell entry into the...