The $238,787 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Stony Brook University aimed at understanding the mechanism of protein secretion through the cell envelope of mycobacteria, including human pathogens like Mycobacterium tuberculosis. The researchers will apply innovative cell wall-specific protein tagging, surface detection, and photocrosslinking methods to track the hierarchical export of ESX-1 substrates to the cell wall and surface. This work is expected to elucidate the functional and molecular relationships governing the transit of these secreted proteins through the mycobacterial cell envelope, thereby advancing fundamental knowledge of this critical pathogenic pathway. The 2-year project commenced on February 1, 2025.
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