This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $128,052 to Virginia Polytechnic Institute & State University (Virginia Tech) to investigate the role of the Rift Valley Fever Virus (RVFV) NSS protein in modulating the host autophagy pathway. The research aims to define the molecular mechanism of the NSS-LC3 interaction and its impact on RVFV pathogenesis in a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $636,101 to the University of Texas Medical Branch at Galveston (UTMB) to investigate the mechanisms of RNA packaging in Rift Valley Fever Virus (RVFV), a mosquito-borne pathogen that poses a serious public health threat. The research aims to elucidate how the segmented viral genome is packaged and co-packaged into...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $790,000.00 in funding to the Regents of the University of Minnesota to conduct research on the immune response to West Nile virus (WNV) and the factors that influence the development of neuroinvasive disease. The goal is to gain a molecular understanding of WNV neuroinvasion, central nervous system immunity, and the...
This $769,115 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to advance the understanding of how neurotropic viruses, including flaviviruses and alphaviruses, can directly enter the central nervous system (CNS) through newly described meningeal structures called arachnoid cuff exit (ACE) points. The research team from The Washington University in St. Louis will...
This $107,948 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to investigate the local and systemic coordination of antiviral immunity by tissue-resident memory CD8 T cells in the skin. The two-year project, running from February 1, 2025 to August 25, 2027, aims to determine whether CD8 tissue-resident memory T cells in the skin can orchestrate an immune...
This federal Project Grant award, totaling $711,555.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The overarching goal of this 5-year project, awarded on May 13, 2025 and running through April 30, 2030, is to contribute to the fundamental understanding of the spatiotemporal transmission dynamics and control of vaccine-preventable childhood infections. The project aims to develop...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $397,135 to Colorado State University to evaluate the potential for zoonotic transmission and human infection by select simian immunodeficiency viruses (SIVs) using a humanized mouse model. The study aims to investigate the cell tropism, CD4 T cell depletion, and sexual transmission capacity of human-adapted SIV...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $648,924 to Iowa State University of Science and Technology to conduct research on the role of mosquito extracellular vesicles in malaria parasite killing and immune priming. The 5-year project, running from February 2025 to January 2030, aims to obtain a mechanistic understanding of how extracellular vesicles...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $192,500.00 to the University of South Alabama to conduct research on the mechanisms of Borrelia burgdorferi central nervous system invasion in a mouse model of Lyme disease. The goal is to identify key pathways of bacterial entry into the central nervous system and associated host immune responses, which could...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 2-year, $544,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Texas Biomedical Research Institute to characterize a novel mouse model for studying the neurological impacts of Chikungunya virus infection. The research aims to determine the mechanisms by which Chikungunya virus infects the brain and evaluate whether the mouse model develops the...