This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $303,449.00 to investigate the role of transposable elements (TEs) in Alzheimer's disease (AD) and related dementias (ADRD). The project aims to leverage large genomic datasets to analyze the prevalence and functional impact of TEs on AD and ADRD phenotypes. Key objectives include: Developing a novel cloud-based computational infrastructure to analyze TE patterns in large AD and ADRD cohorts....
This $407,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of Texas Rio Grande Valley (UTRGV) to investigate the relationship between HIV infection and the onset and progression of Alzheimer's disease (AD) using AD mouse models infected with a chimeric HIV strain. The central hypothesis is that HIV may accelerate the development of cognitive decline in AD. The 2-year study will conduct longitudinal behavioral,...
This Project Grant award of $654,238 from the National Institute on Aging (CFDA 93.866 Aging Research program) supports research to identify the role of senescent neurons in brain aging and Alzheimer's disease and related dementias (ADRD). The primary awardee, the University of Texas Health Science Center at San Antonio, will generate spatial omics data from ADRD brains and mouse models, while the co-investigator team at Washington University will provide expertise in experimental design, data...
This Project Grant award, provided by the National Institute on Aging under CFDA Program 93.866 - Aging Research, supports a $2,516,316 research initiative led by Harvard Medical School to investigate neuronal activity-responsive DNA repair mechanisms and their contribution to cognitive aging and Alzheimer's disease. The key products and services to be delivered under this 3-year grant include: Mapping the landscape of activity-induced DNA double-strand breaks (DSBs) in wild-type mice and...
This Project Grant award of $1,550,462 from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) program, supports a 5-year multidisciplinary study investigating Alzheimer's disease (AD) risk factors in older Black/African American adults living with HIV. The study aims to examine the impacts of the APOE E4 gene variant, HIV disease, and their potential interaction on brain function in this vulnerable population, who may face a greater risk of developing Alzheimer's...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco (UCSF) to conduct research exploring the differential spreading of distinct pathological conformers of proteins associated with Alzheimer's disease, Lewy body dementia, and related dementias. The project aims to identify candidate genes responsible for the selective regional vulnerability to these distinct pathological...
The National Institute on Aging awarded a $480,536 Project Grant under the Aging Research program (CFDA 93.866) to The Jackson Laboratory to fund research aimed at improving treatment for Alzheimer's disease and related dementias (ADRD). The project will assess whether manipulating the angiopoietin/tie2 (ANG/TIE2) signaling pathway can preserve blood-brain barrier (BBB) integrity and prevent cerebrovascular dysfunction, which are major contributors to many ADRDs. The research approach involves...
This federal Project Grant award of $794,341.00, provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, is funding research to investigate the mechanistic roles of cellular senescence and blood-brain barrier dysfunction in mediating pathogen-induced Alzheimer's disease (AD) progression. The key goals are to leverage experimental mouse models, molecular characterization of endogenous retrovirus RNA sensing, and human iPSC models to elucidate how...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,845,311 to the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The overarching goal is to better understand the early trajectory of MCI and AD pathogenesis by leveraging patient-derived induced neurons (iNs) that capture genetic risk factors and...
This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...