Project Grant R01AG103127
- This federal Project Grant award, with identification number R21AG085288, was provided by the National Institute on Aging under the Aging Research grant program (CFDA 93.866). The $434,500 award, with a period of performance from September 1, 2024 to June 30, 2026, will support research into the dopaminergic mechanism underlying familiarity bias and memory interference in aging. The key objectives of this project are to investigate how dysfunction in dopamine neurons projecting to the lateral...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $198,728 to The Rockefeller University on February 21, 2026, under the Aging Research program (CFDA 93.866) to identify cell type-specific RNA expression and regulatory changes in entorhinal cortex clinical samples of Alzheimer's disease. The funded work develops and applies a novel methodology called CLIP-FANS (crosslinking immunoprecipitation-fluorescence activated...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $450,200 on May 15, 2026, under the Aging Research program (CFDA 93.866) to map age-dependent changes in primary sensory neurons and nociceptors. The recipient will deliver a systematic, cell-type-resolved map of how normal aging remodels peripheral sensory neurons housed in the dorsal-root ganglion (DRG). The project employs subtype-specific labeling via a recently published molecular-genetic...
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
- The National Institute on Aging awarded New York University $642,063 under the Aging Research program (CFDA 93.866) on January 15, 2026, to investigate gabaergic circuit targets for modulating entorhinal cortex and hippocampal dynamics in Alzheimer's disease. The research examines vasoactive intestinal peptide and cholecystokinin inhibitory neuron microcircuits within hippocampal area CA1, with the hypothesis that modulating activity in these circuits can improve lateral entorhinal cortex–CA1...
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $2,409,629 in Project Grant funding on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of neuronal ryanodine receptor type 2 (RYR2) in cognitive impairment associated with heart failure. The research aims to uncover the mechanisms by which cognitive impairment develops in both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Wisconsin System Office of Sponsored Programs (operating as University of Wisconsin–Milwaukee) $642,805 under the Aging Research program (CFDA 93.866) on January 15, 2026. The award funds three experiments investigating how older age affects memory integration—the ability to generalize across experiences, make inferences, and accumulate knowledge....
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
The National Institute on Aging, a component of the Department of Health and Human Services, awarded $397,689 to the Research Foundation of The City University of New York (doing business as RFCUNY - Advanced Science Research Center) on September 1, 2026, under the Aging Research program (CFDA 93.866) for Project Grant R01AG103127. The award funds research into pathway-specific vulnerability of dopamine-glutamate neurons in aging and memory. The research examines how dopamine neurons co-releasing glutamate in the ventral tegmental area deteriorate with age and their contribution to cognitive decline. The work employs intersectional viral strategies to characterize dopamine neuron subpopulations, combining fiber photometry, patch-clamp electrophysiology, and matrix-assisted laser desorption/ionization imaging to map age-related dysfunction across specific neural pathways projecting to the lateral entorhinal cortex and nucleus accumbens shell. The research hypothesizes that progressive deterioration of dopamine-glutamate neuron function produces pathway-specific behavioral deficits, initially impairing memory and later extending to motivation, and will assess molecular markers necessary for dopamine-glutamate co-release that decline with age. Performance occurs in New York, New York. The period of performance extends from September 1, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $397.7k | 9/1/26 |