Project Grant R01AG103049
- The National Institute on Aging awarded Duke University $470,881 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate reductive tricarboxylic acid (TCA) cycle metabolism in muscle stem cell aging. The research examines glutamine metabolism pathways in muscle stem cells and how age-related dysfunction in these pathways impairs tissue regeneration. The project uses stable isotope-enabled metabolic flux analysis to characterize both oxidative and reductive glutamine...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Johns Hopkins University $427,625 for Project Grant R21AG102518 on September 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop a human three-dimensional neuromuscular microphysiological system to model skeletal muscle aging ex vivo. The platform integrates primary human muscle stem cells from young (20–30 years) and aged (60–75 years) donors, induced pluripotent...
- The National Institute on Aging awarded the University of Florida $725,528 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on resistance exercise training for older adults with obesity using GLP-1 receptor agonists. The project will evaluate whether progressive, moderate to high-intensity resistance training mitigates muscle loss and strength decline in older adults initiating GLP-1 receptor agonist therapy for obesity treatment. The research addresses...
- The National Institute on Aging awarded the University of Washington $485,375 under the Aging Research program (CFDA 93.866) on September 1, 2026 for Project Grant R21AG102427. The award funds development and expansion of naturally aged three-dimensional engineered muscle tissue (3D-EMT) models to test metabolic and contractile function in vitro as a mechanistic platform for studying sarcopenia. The research examines the contribution of extracellular factors to aged 3D-EMT function and...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
- The National Institute on Aging awarded The Washington University $427,625 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate intramuscular adipose tissue quality and its relationship to muscle weakness in aging. The research addresses the mechanism by which ectopic adipose tissue accumulates within muscle boundaries during aging, impairing muscle contraction through secreted signals. The project tests the hypothesis that intramuscular adipose tissue quality...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
The National Institute on Aging awarded the University of Florida $540,345 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research into a metabolic sensor-driven metabolite repair system that maintains muscle stem cell homeostasis. The research addresses loss of skeletal muscle stem cell function as a central driver of impaired regeneration, progressive muscle wasting, and frailty in aging, muscular dystrophies, and metabolic diseases. The project investigates how CREB-regulated transcriptional coactivators (CRTCs) preserve mitochondrial respiration in muscle stem cells by controlling the mitochondrial metabolite repair enzyme FAHD2A, which prevents the buildup of toxic enol-oxaloacetate and safeguards oxidative phosphorylation and stem cell proliferation. Preliminary studies indicate that FAHD2A levels decline with age in both mouse and human muscle stem cells, linking disruption of this pathway to stem cell attrition and regenerative failure. Work is performed at the University of Florida in Gainesville, Florida. The project period extends from September 1, 2026, through May 31, 2031. The award is classified as a Project Grant under the Aging Research assistance listing, which supports biomedical, social, and behavioral research directed toward understanding the aging process and diseases affecting older populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $540.3k | 9/1/26 |