Project Grant R01AG102716
- The National Institute on Aging awarded Mayo Clinic $729,906 on September 3, 2026, under the Aging Research program (CFDA 93.866) to investigate the neurobiological substrates of falls in cognitively unimpaired older adults. The research uses dual-task paradigms that simultaneously engage motor and cognitive brain systems to characterize subclinical gait impairment patterns among cognitively unimpaired individuals who experience falls. The study assesses how gait impairment relates to...
- The National Institute on Aging awarded Mayo Clinic a Cooperative Agreement totaling $4,496,369 on August 18, 2026, under the Aging Research program (CFDA 93.866) to establish and operate the Mayo Clinic Study of Aging (MCSA) as a multi-site platform for validating and deploying blood-based biomarkers to guide clinical care in cognitive aging. The MCSA will develop and test biomarkers to quantify multifactorial contributions to cognitive impairment, including Alzheimer's disease, cerebrovascular...
- The National Institute on Aging awarded Mayo Clinic $660,157 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of BRD4 in enhancing preservation quality of donor hearts from older individuals through three-dimensional chromosomal restructuring. The project addresses a critical shortage in the donor heart supply for transplantation. Older donor hearts are often rejected due to elevated risk of primary graft dysfunction; in 2024, only 303 hearts from...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded Mayo Clinic $678,987 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the impact of menopause on blood pressure regulation during exercise. The research tests whether locomotor muscle afferent feedback and respiratory muscle work contribute to exaggerated blood pressure responses and impaired leg blood flow in post-menopausal women during submaximal exercise. The project has two specific aims: to determine if locomotor...
- The National Institute on Aging awarded The Salk Institute for Biological Studies $1.359 million on February 15, 2026, under the Aging Research program (CFDA 93.866) to characterize activity-dependent changes to neuronal populations in the spinal dorsal horn during aging and determine functional consequences for sensorimotor behaviors. The research selectively perturbs activity in different classes of cutaneous afferent neurons to identify inputs that support cell survival in adult mice,...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging at the Department of Health and Human Services awarded Mayo Clinic $878,516 in project grant funding on June 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a six-week clinical study examining high-resistance inspiratory muscle strength training as an intervention to reduce sympathetic nerve activity and improve sleep in postmenopausal women experiencing hot flashes. The research addresses vasomotor symptoms associated with menopause, which...
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
- The National Institute on Aging awarded the University of Massachusetts Medical School $452,783 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate molecular mechanisms of neuronal cell death and protection against neurodegeneration. The award funds research into how context-specific molecular mechanisms protect neurons against age-related degeneration, using C. elegans models of excitotoxicity and oxidative stress. The project will determine how TIR-1/SARM1, a...
The National Institute on Aging awarded Mayo Clinic $678,684 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate the neural mechanisms of respiratory dysfunction in older age. The research explores how impaired autophagy in phrenic motor neurons contributes to selective loss of higher-force motor units with advancing age, and whether restoring autophagy prevents this loss. The project employs loss-of-function and gain-of-function experiments using conditional knockout mice and pharmacological autophagy induction to test two complementary mechanistic hypotheses: that autophagy impairment causes age-related motor unit loss (Aim 1) and that autophagy restoration is sufficient to prevent it (Aim 2). Work is performed at Mayo Clinic in Rochester, Minnesota, with a period of performance extending from September 1, 2026, through May 31, 2031. The award addresses age-related respiratory decline, which carries significant consequences for quality of life, morbidity, and mortality, particularly the inability to generate sufficient force for effective airway clearance and reduced resistance to pneumonia and respiratory complications in older adults.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $678.7k | 8/28/26 |