Project Grant R01AG101908
- The National Institute on Aging awarded Vanderbilt University Medical Center $2,129,341 on August 15, 2026, under the Aging Research program (CFDA 93.866) to conduct multiscale functional assessment of white matter across the life span. The research investigates blood oxygenation level-dependent (BOLD) signals in white matter using functional magnetic resonance imaging (fMRI) to characterize how white matter function evolves across developmental, adult, and aging stages. The project quantifies...
- The National Institute on Aging awarded Vanderbilt University $421,250 on July 1, 2026, through the Aging Research program (CFDA 93.866) to develop a programmable RNA-based sensing circuit that targets inflammatory reactive astrocytes in Alzheimer's disease. The project engineers a single, compact RNA vector that harnesses endogenous ADAR enzymes to selectively modulate disease-driving astrocytes based on their transcriptional state. The system produces therapeutic payloads, such as...
- The National Institute on Aging awarded Vanderbilt University Medical Center $3,079,819 for a Project Grant (R01AG092663) on January 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research probing mechanistic links between endothelial aging and dementia. The recipient will passage human induced pluripotent stem cells differentiated to endothelial cells (hiPSC-ECs) obtained from healthy adults and individuals with vascular contributions to cognitive impairment and...
- The National Institute on Aging awarded $526,607 to Wake Forest University on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational imaging frameworks that integrate neuroimaging with multi-omics data to identify Alzheimer's disease subtypes and model neurodegenerative progression with calibrated uncertainty. The project, titled "Neuroimaging Multi-Omics Fingerprints for Subtyping and Uncertainty-Aware Prediction of Alzheimer's Disease," will...
- The National Institute on Aging awarded Rush University Medical Center $656,503 under CFDA 93.866 (Aging Research) on September 1, 2026, to develop and validate an in-vivo MRI-based classifier for detecting cerebral amyloid angiopathy in community-dwelling older adults. The project combines multimodal MRI imaging with neuropathological data to create a machine-learning classifier capable of identifying cerebral amyloid angiopathy—a common age-related pathology affecting up to 80 percent of older...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Vanderbilt University on May 15, 2026, under the Aging Research program (CFDA 93.866) to define characteristics of a resilient organelle interactome during aging. The research applies advanced 3D electron microscopy and artificial intelligence-based image analysis to map organelle interactions in Caenorhabditis elegans model organisms across the aging process. The work compares age-dependent...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $511,574 on July 1, 2026, under the Aging Research program (CFDA 93.866) to develop statistical methods for precision health management in high-risk Alzheimer's disease populations. The recipient will conduct three integrated research activities. Aim 1 involves evidence synthesis through semi-automated systematic review and meta-analyses of published studies to synthesize evidence on prognostic...
The National Institute on Aging awarded Vanderbilt University Medical Center $707,033 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate novel statistical machine learning approaches that leverage baseline neuroimaging data to increase the statistical power and cost-effectiveness of clinical trials in Alzheimer's disease and late-life depression. The project addresses the challenge of efficiently utilizing rich neuroimaging datasets collected at baseline in randomized clinical trials. Accounting for measured baseline covariates through advanced statistical methods can reduce standard error in treatment effect estimators and uncover treatment effect heterogeneity that might otherwise mask real benefits to patient subgroups. The award funds methodology development that will enable trial sponsors to design more efficient studies while revealing potential therapeutic targets and biomarkers that modulate treatment response. The work is performed in Forest Hills, Tennessee, with performance through May 31, 2031. This is a Project Grant, the standard assistance type for individual research projects under the National Institute on Aging's aging research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $707.0k | 8/27/26 |