Project Grant R01AG104704
- The National Institute on Aging awarded Duke University $444,125 under the Aging Research program (CFDA 93.866) on September 3, 2026, to investigate bidirectional relationships between plasma tau phosphorylation markers and postoperative delirium. The project examines how Alzheimer's disease pathology, reflected in blood-based biomarkers such as threonine-217 phosphorylated tau (PTAU217), may increase postoperative delirium risk and how postoperative delirium may alter longitudinal...
- The National Institute on Aging awarded $1,161,596 to the University of Texas Health Science Center at Houston on August 1, 2026, under the Aging Research program (CFDA 93.866) to identify biomarkers and mechanisms underlying perioperative neurocognitive disorders (PND), including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorders that increase morbidity, mortality, and long-term dementia risk. The research investigates whether non-brain-derived...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded Weill Medical College of Cornell University $172,260 on July 1, 2026, under the Aging Research program (CFDA 93.866) to characterize the relationship between electroencephalographic burst-suppression and postoperative delirium in the context of corticothalamic function. The recipient will investigate biomarkers for postoperative delirium, a neurocognitive disturbance...
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $761,496 on June 15, 2026, to investigate epigenetic mechanisms linking delirium and cognitive decline under the Aging Research program (CFDA 93.866). The recipient will test the hypothesis that epigenetic risk, measured by DNA methylation, identifies individuals with a vulnerable brain predisposed to delirium, cognitive decline, and Alzheimer's disease and Alzheimer's disease-related dementias in the setting of...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $691,683 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the glymphatic system's role in perioperative neurocognitive disorder. The research characterizes how anesthesia and surgery impair glymphatic function—the brain's perivascular clearance pathway for neurotoxic proteins including beta-amyloid and phosphorylated tau—particularly in aging and Alzheimer's...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Duke University $493,972 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cell type-specific epitranscriptomic regulation in the brain during aging and Alzheimer's disease. The research will determine how age-dependent differential methylation of adenosine (M6A) in distinct brain cell types influences the expression of genes associated with Alzheimer's disease. The...
- The National Institute on Aging awarded The Feinstein Institutes For Medical Research $698,456 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop machine learning models that identify and predict delirium in hospitalized older adults. The project addresses two clinical gaps: the high rate of missed delirium diagnoses in emergency departments (over 75% missed despite intensive screening) and the need to identify high-risk patients during hospital admission to enable...
- The National Institute on Aging, under the Department of Health and Human Services, awarded Duke University $627,830 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a portable diagnostic system for Alzheimer's disease detection using circulating microRNA biomarkers. Duke's project, titled ADMIRE (Alzheimer's Detection via miRNA Evaluation), integrates two technologies: an amplification-free microRNA biosensing modality called the Inverse Molecular Sentinel and a...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
The National Institute on Aging awarded Duke University $647,811 on September 1, 2026, under the Aging Research program (CFDA 93.866) to define the role of lipocalin-2 in postoperative delirium. The research investigates the molecular mechanisms underlying postoperative delirium, a neurologic disorder with significant morbidity, prolonged hospitalization, and increased risk of Alzheimer's disease and related dementias. The project uses a postoperative delirium mouse model to characterize how lipocalin-2 (LCN2) expression in neutrophils and brain endothelial cells triggers blood-brain barrier dysfunction and microglial activation following orthopedic surgery. Prior work identified LCN2 induction in both neutrophils and brain endothelial cells after surgery, with elevated LCN2 expression in cerebrospinal fluid from patients with postoperative delirium compared to unaffected patients. The project aims to establish LCN2 as a therapeutic target for delirium prevention by determining its contribution to barrier dysfunction and neuroinflammation. Duke University's Office of Research Administration serves as the recipient. Performance occurs in Durham, North Carolina, with a period of performance from September 1, 2026, through June 30, 2031. The award is a Project Grant, the standard assistance type under the Aging Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $647.8k | 8/25/26 |