Project Grant R01AG098122
- The National Institute on Aging awarded Duke University $444,125 under the Aging Research program (CFDA 93.866) on September 3, 2026, to investigate bidirectional relationships between plasma tau phosphorylation markers and postoperative delirium. The project examines how Alzheimer's disease pathology, reflected in blood-based biomarkers such as threonine-217 phosphorylated tau (PTAU217), may increase postoperative delirium risk and how postoperative delirium may alter longitudinal...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $691,683 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the glymphatic system's role in perioperative neurocognitive disorder. The research characterizes how anesthesia and surgery impair glymphatic function—the brain's perivascular clearance pathway for neurotoxic proteins including beta-amyloid and phosphorylated tau—particularly in aging and Alzheimer's...
- The National Institute on Aging awarded Duke University $647,811 on September 1, 2026, under the Aging Research program (CFDA 93.866) to define the role of lipocalin-2 in postoperative delirium. The research investigates the molecular mechanisms underlying postoperative delirium, a neurologic disorder with significant morbidity, prolonged hospitalization, and increased risk of Alzheimer's disease and related dementias. The project uses a postoperative delirium mouse model to characterize how...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded Weill Medical College of Cornell University $172,260 on July 1, 2026, under the Aging Research program (CFDA 93.866) to characterize the relationship between electroencephalographic burst-suppression and postoperative delirium in the context of corticothalamic function. The recipient will investigate biomarkers for postoperative delirium, a neurocognitive disturbance...
- The National Institute on Aging awarded the University of Texas Medical Branch at Galveston $1.788 million on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the interplay between microglia and tau oligomer polymorphs in cognitive resilience among individuals with Alzheimer's disease neuropathology who remain cognitively intact. The project tests the hypothesis that brain-derived tau oligomers isolated from cognitively resilient individuals exhibit reduced toxicity...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
- The National Institute on Aging awarded The Johns Hopkins University $653,100 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate poly(ADP-ribose) polymerase 1 (PARP1) and macrophage migration inhibitory factor (MIF) nuclease activity in tau-related neurodegeneration and cognitive dysfunction. The research will examine neurobehavior and neuropathology in PS19 transgenic mice models with PARP1 knockout and MIF nuclease-deficient or tautomerase-deficient genetic...
- The National Institute on Aging awarded The University of Texas Health Science Center at San Antonio $150,000 on September 18, 2025, under the Aging Research program (CFDA 93.866) to host five international NeurEpiOmics workshops spanning 2025 through 2029. The workshops combine didactic talks by field leaders with hands-on training and discussions to build an interdisciplinary network of researchers fluent in neurology, brain imaging, epidemiology, genetics, multiomics, and ethics. Each...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $249,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate an innovative genetic platform for de-risking g-secretase modulator therapeutics in Alzheimer's disease. The award funds two primary aims. Aim 1 involves using CRISPR/Cas9 engineering and structure-informed design to generate and validate a novel...
The National Institute on Aging awarded $1,161,596 to the University of Texas Health Science Center at Houston on August 1, 2026, under the Aging Research program (CFDA 93.866) to identify biomarkers and mechanisms underlying perioperative neurocognitive disorders (PND), including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorders that increase morbidity, mortality, and long-term dementia risk. The research investigates whether non-brain-derived phosphorylated tau at threonine 217 (PTAU217) can be generated in blood and serves as a biomarker for PND; whether pre- and postoperative blood PTAU217, gut microbiota, and their metabolites indole-3-propionic acid and butyric acid predict or enhance PND development; and whether specific gut microbiota profiles regulate GSK3B activity to promote non-brain-derived PTAU217 generation and PND pathogenesis. The research also examines blood inflammatory cytokines including interleukin-6 and C-reactive protein as associated factors in postoperative delirium. The award extends through April 30, 2031, with place of performance in Houston, Texas. This is a Project Grant, the standard NIH research award mechanism for investigator-initiated biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/1/26 | ||
| Not listed | $580.8k | 7/31/26 |