Project Grant R01AG097704
Award Date 9/1/26
Completion Date 5/31/31
Dollars Obligated $665K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Durham, NC 27710, USA
Similar Awards
- The National Institute on Aging awarded Duke University $470,881 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate reductive tricarboxylic acid (TCA) cycle metabolism in muscle stem cell aging. The research examines glutamine metabolism pathways in muscle stem cells and how age-related dysfunction in these pathways impairs tissue regeneration. The project uses stable isotope-enabled metabolic flux analysis to characterize both oxidative and reductive glutamine...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Duke University $493,972 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cell type-specific epitranscriptomic regulation in the brain during aging and Alzheimer's disease. The research will determine how age-dependent differential methylation of adenosine (M6A) in distinct brain cell types influences the expression of genes associated with Alzheimer's disease. The...
- Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
- Federal Project Grant Award Summary Emory University received a $3.25 million Project Grant from the National Institute on Aging (CFDA 93.866: Aging Research) effective September 1, 2025, through August 31, 2029. This award supports biomedical research investigating the role of indole and related metabolites produced by commensal microbiota in promoting mobility and healthspan during aging. The research project focuses on understanding how indole compounds, secreted by beneficial bacteria,...
- The National Institute on Aging awarded The Jackson Laboratory $506,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop an age-stratified human gut-on-chip model that integrates organoid-derived young and old colon epithelia with patient-derived microbiomes within a dynamically perfused, oxygen-controlled microphysiological environment. The recipient will establish the first such platform capable of sustaining obligate anaerobes and examining how aging-related...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of Missouri System $676,608 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of the gut-brain axis in Alzheimer's disease mitigation through a translational study combining human and preclinical animal experiments. The project examines how dysbiosis—microbial imbalance—correlates with Alzheimer's disease biomarkers (amyloid plaques, tau...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Vanderbilt University on May 15, 2026, under the Aging Research program (CFDA 93.866) to define characteristics of a resilient organelle interactome during aging. The research applies advanced 3D electron microscopy and artificial intelligence-based image analysis to map organelle interactions in Caenorhabditis elegans model organisms across the aging process. The work compares age-dependent...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded Duke University $444,125 under the Aging Research program (CFDA 93.866) on August 15, 2026, to investigate B cell rejuvenation as a mechanism to improve bone fracture healing in aged populations. The project will test whether maresin 1 treatment of B cells isolated from aged mice can restore interleukin-7 receptor (IL7R) expression, enhance anti-inflammatory cytokine secretion, and improve fracture healing outcomes when injected at fracture sites. The...