Project Grant R01AG097492
- This federal Project Grant award of $416,625 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research at Saint Louis University (SLU) to investigate the effects of aging, sex, and hormonal status on atherosclerotic cardiovascular disease (CVD). The key objectives are to: 1) comprehensively map inflammatory cell profiles and cell-cell communication networks in atherosclerotic plaques of young and old male and female mice, including old...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $431,750 aims to isolate and characterize peptide ligands targeting vascular endothelial cells (VECs) in young versus aged mice in vivo and senescent versus non-senescent murine VECs in vitro. The primary objectives are to enhance the understanding of molecular mechanisms and age-related pathologies associated with vascular dysfunction during aging. The project seeks to...
- The federal Project Grant award R21AG086723 for $466,125.00 was granted by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine to characterize age-related changes in the testis stem cell niche. The key objectives are to: (1) identify genes differentially expressed in young and aged testis niche cells and those dependent on activin signaling, and (2) develop new tools to monitor activin and follistatin proteins and pathway activity in the fly...
- This Project Grant award of $429,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to define the role of decreased estradiol in modulating crotonylation of myofilament proteins in aged female hearts. The research, conducted by the University of Colorado-Denver, seeks to better understand the biochemical pathways modulated in the female heart in response to estradiol loss after menopause. This may provide insights to improve treatment of post-menopausal women with...
- This $847,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by The Medical College of Wisconsin, Inc. (MCW) to determine whether extracellular vesicle-enclosed Y5-RNA mediates the age-dependent impairment of angiogenesis (the formation of new blood vessels). The research aims to examine if decreases in Y5-RNA in endothelial cell-derived extracellular vesicles contribute to endothelial cell senescence and impaired angiogenesis in aged...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,445,585 to The Trustees of Columbia University in the City of New York to investigate the molecular mechanisms underlying human ovarian aging and its connection to women's health outcomes. The research aims to gain a better understanding of how ovarian aging progresses at the cellular level compared to other tissue types, with the goal of identifying potential interventions to delay...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $161,000.00 to the University of California, Davis to investigate sex differences in atrial remodeling and arrhythmia risk in aging. The project will run from September 30, 2024 to August 31, 2026 and aims to advance the understanding of how biological sex impacts the development of atrial fibrillation, a common age-related heart condition. The research will leverage UC Davis's expertise in...
- This $880,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to examine the effects of daily stress, sleep, and sex hormones on accelerated vascular aging in premenopausal midlife women. The 2-year study, starting November 2024, will investigate how emotional reactivity to daily stressors and sleep variability contribute to vascular dysfunction prior to menopause, and how these factors interact with changes in estradiol levels. The...
- This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports comprehensive scientific investigations to understand the biological, clinical, and social aspects of aging, with a particular emphasis on Alzheimer's disease and related dementias. The total award amount is $547,898.00, and the project is scheduled to run from June 1, 2025 to March 31, 2029. The primary objective of this grant is to study the impact of sex on mitochondrial...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $1,497,502 cooperative agreement to Cedars-Sinai Medical Center. The award, titled "The Microvascular Aging Effects - Women's Evaluation of Systemic Aging Tenacity in Heart, Brain and Frailty (MAE-WEST HBF) ("You Are Never Too Old to Become Younger!")," will support a specialized research center focused on understanding the role of small vessel (microvascular)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to elucidate the molecular basis of sex-dependent differences in endothelial cell (EC) functions that may shape the outcomes of angiogenesis-driven diseases and aging. The $659,309 award, commencing on December 15, 2025 and concluding on November 30, 2030, will be carried out by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The research aims to investigate how Toll-like receptor (TLR) 2/4 signaling in female ECs contributes to increased inflammation, reactive oxygen species, and reduced angiogenic potential compared to male ECs, which may underlie the observed male-female health-survival paradox in age-associated disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $659.3k | 12/12/25 |