This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), aims to elucidate the function of the nuclear-encoded humanin isoform gene MTRNR2L1 and explore its potential implications in the pathogenesis of neovascular age-related macular degeneration (AMD). The awarded funds of $240,713 will support research activities from February 1, 2025 to January 31, 2027 at The Research Foundation for the State University of New York (RF...
The National Eye Institute (NEI) awarded a $253,500 Project Grant (CFDA 93.867 - Vision Research) to the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD). The project aims to leverage induced pluripotent stem cell technology to develop an in vitro human outer blood-retina barrier model that can spontaneously form sub-retinal...
This National Eye Institute (NEI) Vision Research federal grant award (CFDA 93.867) provides $862,580 to the University of Colorado-Denver to investigate the role of mitochondrial function and genetics in the etiology of age-related eye diseases. The project, titled "The Aging Eyes Study: Mitochondrial Dysfunction as a Driver of Age-Related Vision Loss," aims to identify mitochondrial function as a marker of biological aging in the eyes and determine its impact on susceptibility to...
This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) totaling $1,330,026 will support the development of two novel mouse models of geographic atrophy, the advanced form of dry age-related macular degeneration (AMD). The research will evaluate the potential of the novel antioxidant deuterated docosahexaenoic acid (D-DHA) to protect the retinal pigment epithelium (RPE) from oxidative stress-induced degeneration. The project will...
This $161,922 Project Grant award, funded by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research investigating the mechanisms by which mitochondrial protein import stress can induce myokine signaling and the impact on metabolic and cardiovascular health, particularly during aging. The research, conducted by The Research Foundation for The State University of New York, Upstate Medical Center, aims to uncover the underlying processes by which mitochondrial...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $254,808 to the University of California, San Diego (UCSD) to investigate the role of heparan sulfate (HS) in the development of drusen, a hallmark of age-related macular degeneration (AMD). The project aims to determine how AMD risk factors are associated with changes in the composition of glycosaminoglycans (GAGs), including HS, in Bruch's membrane. It will also examine...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $673,747 to New York University School of Medicine to develop a visible-to-near-infrared spanning optical coherence tomography (OCT) system. The system will enable high-resolution, depth-resolved imaging of key biomarkers related to aging and early age-related macular degeneration (AMD), including macular pigments and retinal pigment epithelium melanosomes. The goal is to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $935,708.00 to Georgia Tech Research Corp to investigate the spatial and temporal heterogeneity of mitochondria during aging using advanced in vivo chemical imaging techniques. The research aims to unravel how changes in mitochondrial dynamics, including their interactions with lipid droplets, subcellular localization, and morphology, impact physiological homeostasis across different tissues...
This Project Grant award from the National Institute on Aging, under the Aging Research federal grant program (CFDA 93.866), provides $308,000.00 to the Regents of the University of Minnesota to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial ribonucleoprotein granule dynamics and utilize optogenetic control of Aβ42 and mitochondrial ribonucleoprotein granules in mitochondria. The overarching goal is to identify the mechanisms by which Aβ42 interferes with mitochondrial...
The National Eye Institute (NEI) awarded a $3,120,397 Project Grant (CFDA 93.867 - Vision Research) to The Medical University of South Carolina to assess the role of the complement pathway in age-related macular degeneration (AMD). The project aims to utilize a 3D tissue chip model of the retinal pigment epithelium (RPE) and choroid to characterize the effects of genetic risk factors and environmental stressors on complement activation and AMD progression. Sub-awards were made to The...