The National Heart, Lung, and Blood Institute (NHLBI) awarded a $570,537 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of California, Davis to investigate the mechanisms by which calcium dysregulation in human atrial fibroblasts contributes to atrial fibrosis and the progression of atrial fibrillation. The project aims to establish a multiscale, mechanistic understanding of how changes in calcium homeostasis within atrial fibroblasts drive their...
This $416,625 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year study at Saint Louis University to investigate the effects of age, sex, and hormonal status on atherosclerotic cardiovascular disease (CVD). The researchers will use mouse models to comprehensively map the transcriptomic profiles of atherosclerotic plaques, focusing on inflammatory cell clusters, cell-to-cell communication networks, and markers linked to plaque stability and...
The National Institute on Aging (NIA) awarded a $241,500 Project Grant (CFDA 93.866 - Aging Research) to the University of California, Davis (UC Davis) to investigate mechanisms of nutrient-sensitive protein modifications that regulate daily biological rhythms. The overall goal is to identify proteins rhythmically modified by O-GlcNAcylation and phosphorylation, and examine how mistimed feeding disrupts these rhythmic post-translational modification profiles in key mammalian organs. The 2-year...
This U01 Cooperative Agreement from the National Institute on Aging (NIA), under the Federal Grant Program for Aging Research (CFDA 93.866), provides $2,046,568.00 in funding to the Buck Institute for Research on Aging to conduct research to identify organ-specific blood biomarkers of aging and assess their effects on cardiovascular health. The project will use deep learning and multi-omics data from large longitudinal cohorts to generate sex-specific estimators of organ biological age and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the reversal of cardiac aging through Urolithin A treatment. The $647,672 award to the University of Washington aims to study how Urolithin A, a metabolite derived from polyphenols, can help mitigate age-related mitochondrial dysfunction and associated cardiovascular issues like hypertrophy, diastolic dysfunction, and reduced contractility in the...
This $2,114,698 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) will support research at the University of North Texas Health Science Center at Fort Worth to investigate the role of sex and the brain hormone angiotensin II in Alzheimer's disease. The 5-year project aims to determine how sex chromosomes, sex hormones, and brain-derived hormones interact to modulate angiotensin II activation and associated oxidative stress and cognitive...
This Project Grant award from the National Institute on Aging (CFDA 93.866, Aging Research) to The Regents of the University of California, San Francisco (UCSF) totals $450,688 and runs from June 15, 2024 to May 31, 2026. The project aims to investigate the molecular-level changes in cardiometabolic tissues that occur during and after the menopausal transition in women. Key objectives include: Using a mouse model of ovarian follicle depletion to identify menopause-induced changes in chromatin...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $635,224 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of California, Davis. This 4-year award, spanning July 1, 2024 to May 31, 2028, will support research to investigate the metabolic control of cardiac pacemaking activity. The project aims to test the hypothesis that regional variations in the sino-atrial node's (SAN) vascular supply, myocyte ATP dynamics, and stochastic...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
The National Institute on Aging (NIA) awarded a $331,187 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Brandeis University. The 4-year award, effective September 1, 2024, will support research to understand the role of retrotransposon activity as a potential driver of aging and age-associated diseases. Using the Drosophila model system, the project aims to characterize how increased transposition may contribute to the physiological decline associated with aging....